2. Gene
  3. Alkbh1 - alkB homolog 1, histone H2A dioxygenase Gene

Alkbh1 - alkB homolog 1, histone H2A dioxygenase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Abh; alkB; hABH; Alkbh; 2700073G19Rik

Gene ID: 211064 | Gene type: protein coding

About Alkbh1

Summary

Enables chemoattractant activity and oxidative DNA demethylase activity. Involved in DNA demethylation and tRNA demethylation. Acts upstream of or within several processes, including generation of neurons; negative regulation of neuron apoptotic process; and placenta development. Located in euchromatin. Is expressed in several structures, including branchial arch; central nervous system; gonad; hemolymphoid system gland; and limb bud. Orthologous to human ALKBH1 (alkB homolog 1, histone H2A dioxygenase). [provided by Alliance of Genome Resources, Apr 2022]

Alkbh1 Products(1)

mRNA Protein Name
NM_001102565.1 NP_001096035.1 nucleic acid dioxygenase ALKBH1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables broad specificity oxidative DNA demethylase activity IDA
IDA: Inferred from direct assay
27027282 MGI
enables chemoattractant activity IDA
IDA: Inferred from direct assay
16860792 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18163532 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cell differentiation IMP
IMP: Inferred from mutant phenotype
18163532 MGI
acts upstream of or within developmental growth IMP
IMP: Inferred from mutant phenotype
18163532 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
18163532 MGI
acts upstream of or within negative regulation of neuron apoptotic process IDA
IDA: Inferred from direct assay
16860792 MGI
acts upstream of or within neuron migration IDA
IDA: Inferred from direct assay
16860792 MGI
acts upstream of or within neuron projection development IDA
IDA: Inferred from direct assay
16860792 MGI
acts upstream of or within placenta development IMP
IMP: Inferred from mutant phenotype
18163532 MGI
involved in positive regulation of gene expression, epigenetic IDA
IDA: Inferred from direct assay
27027282 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
18163532 MGI
involved in regulation of translational initiation by tRNA modification IMP
IMP: Inferred from mutant phenotype
27745969 MGI
Cellular Component GO Annotation Evidence Reference Source
located in euchromatin IDA
IDA: Inferred from direct assay
18163532 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nucleic acid dioxygenase ALKBH1

Alkylated DNA repair protein alkB homolog 1

DNA 6mA demethylase

DNA N6-methyl adenine demethylase ALKBH1

DNA demethylase ALKBH1

DNA lyase ABH1

DNA oxidative demethylase ALKBH1

alkB, alkylation repair homolog 1

alpha-ketoglutarate-dependent dioxygen

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-163385 ALKBH1-IN-1 Inhibitor 98.88% Unkown
HY-158998 ALKBH1-IN-2 99.16% Unkown
HY-168044 ALKBH1-IN-3 Activator / Unkown
HY-169131 ALKBH1-IN-3 prodrug Activator / Unkown
HY-RS00603 ALKBH1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18694 Alkbh1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25181 Alkbh1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Alkbh1 NCBI NCBI:8846