Bhlhe40 - basic helix-loop-helix family, member e40 Gene

Mus musculus

Also known as CR8; Dec1; Bhlhb2; Clast5; Sharp2; Stra13; Stra14; C130042M06Rik

Gene ID: 20893 | Gene type: protein coding

About Bhlhe40

Summary

This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with Arntl or compete for E-box binding sites in the promoter of Per1 and repress Clock/Arntl's transactivation of Per1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. [provided by RefSeq, Feb 2014]

Bhlhe40 Products(1)

mRNA	Protein	Name
NM_011498.4	NP_035628.1	class E basic helix-loop-helix protein 40

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	12297495	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15147242	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15147242	MGI
enables E-box binding	IDA IDA: Inferred from direct assay	12397359	MGI
enables MRF binding	IDA IDA: Inferred from direct assay	17487425	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15147242	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IDA IDA: Inferred from direct assay	17487425	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12297495	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in circadian regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18411297	MGI
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	19786558	MGI
involved in entrainment of circadian clock by photoperiod	IMP IMP: Inferred from mutant phenotype	18411297	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12297495	MGI
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	30012868	MGI
involved in regulation of circadian rhythm	IMP IMP: Inferred from mutant phenotype	30012868	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	12297495	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

class E basic helix-loop-helix protein 40

E47 interaction protein 1	basic helix-loop-helix domain containing, class B2
class B basic helix-loop-helix protein 2	cytokine response gene 8
differentially expressed in chondrocytes protein 1	eip1 (E47 interaction protein 1)
stimulated by retinoic

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01493	BHLHE40 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18433	Bhlhe40 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24914	Bhlhe40 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bhlhe40	NCBI	NCBI:8553

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