2. Gene
  3. Eif4g1 - eukaryotic translation initiation factor 4, gamma 1 Gene

Eif4g1 - eukaryotic translation initiation factor 4, gamma 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as eIF4GI; eIF-4G1; eIF-4G 1; E030015G23Rik; eIF-4-gamma 1

Gene ID: 208643 | Gene type: protein coding

About Eif4g1

Summary

This gene encodes a member of the eukaryotic translation initiation factors (eIF) that play important roles in translation initiation by mediating recruitment of additional initiation factors and providing a scaffold for ribosome/mRNA-bridging. Along with eIF4A and eIF4E, the encoded protein forms the eIF4F complex that bridges the 5' UTR with the polyadenylated 3' UTR resulting in mRNA circularization, enhanced translation initiation and mRNA stability. Through its association with eIF3, the encoded protein mediates recruitment of the 43S pre-initiation complex to mRNA. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes for this gene have been identified on chromosomes 2 and 13. [provided by RefSeq, Jan 2015]

Eif4g1 Products(11)

mRNA Protein Name
NM_001304432.2 NP_001291361.1 eukaryotic translation initiation factor 4 gamma 1 isoform c
NM_001403460.1 NP_001390389.1 eukaryotic translation initiation factor 4 gamma 1 isoform 3
NM_001403461.1 NP_001390390.1 eukaryotic translation initiation factor 4 gamma 1 isoform 3
NM_001403462.1 NP_001390391.1 eukaryotic translation initiation factor 4 gamma 1 isoform 4
NM_001403463.1 NP_001390392.1 eukaryotic translation initiation factor 4 gamma 1 isoform c
NM_001403464.1 NP_001390393.1 eukaryotic translation initiation factor 4 gamma 1 isoform 5
NM_001403465.1 NP_001390394.1 eukaryotic translation initiation factor 4 gamma 1 isoform 6
NM_001403466.1 NP_001390395.1 eukaryotic translation initiation factor 4 gamma 1 isoform 7
NM_001403467.1 NP_001390396.1 eukaryotic translation initiation factor 4 gamma 1 isoform 8
NM_001403468.1 NP_001390397.1 eukaryotic translation initiation factor 4 gamma 1 isoform 9
NM_145941.4 NP_666053.2 eukaryotic translation initiation factor 4 gamma 1 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16541103 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within behavioral fear response IGI
IGI: Inferred from genetic interaction
24990923 MGI
acts upstream of neuron differentiation IMP
IMP: Inferred from mutant phenotype
25456498 MGI
acts upstream of or within positive regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
25456498 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12388085 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

eukaryotic translation initiation factor 4 gamma 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-19560 SBI-0640756 Inhibitor 99.75% Unkown
HY-RS04281 EIF4G1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-164524 SBI-0640726 Inhibitor / Unkown
HY-RS19254 Eif4g1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25743 Eif4g1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Eif4g1 NCBI NCBI:1981