2. Gene
  3. Aph1b - aph1 homolog B, gamma secretase subunit Gene

Aph1b - aph1 homolog B, gamma secretase subunit Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as APH-1b; aph-1beta

Gene ID: 208117 | Gene type: protein coding

About Aph1b

Summary

Predicted to enable endopeptidase activator activity and protein-macromolecule adaptor activity. Acts upstream of or within several processes, including amyloid-beta formation; chemical synaptic transmission; and prepulse inhibition. Part of gamma-secretase complex. Is expressed in several structures, including nervous system. Human ortholog(s) of this gene implicated in coronary artery disease. Orthologous to human APH1B (aph-1 homolog B, gamma-secretase subunit). [provided by Alliance of Genome Resources, Apr 2022]

Aph1b Products(1)

mRNA Protein Name
NM_177583.4 NP_808251.1 gamma-secretase subunit APH-1B
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within amyloid-beta formation IGI
IGI: Inferred from genetic interaction
16371134 MGI
acts upstream of or within membrane protein ectodomain proteolysis IGI
IGI: Inferred from genetic interaction
18626010 MGI
acts upstream of or within prepulse inhibition IGI
IGI: Inferred from genetic interaction
18626010 MGI
acts upstream of or within short-term memory IGI
IGI: Inferred from genetic interaction
18626010 MGI
acts upstream of or within synaptic transmission, dopaminergic IGI
IGI: Inferred from genetic interaction
18626010 MGI
acts upstream of or within synaptic transmission, glutamatergic IGI
IGI: Inferred from genetic interaction
18626010 MGI
Cellular Component GO Annotation Evidence Reference Source
part of gamma-secretase complex IDA
IDA: Inferred from direct assay
16371134 MGI
part of gamma-secretase complex IGI
IGI: Inferred from genetic interaction
18626010 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

gamma-secretase subunit APH-1B

APH1B homolog

anterior pharynx defective 1b homolog

anterior pharynx defective 1c homolog

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-156011 PSEN1-IN-1 Inhibitor / Unkown
HY-156012 PSEN1-IN-2 Inhibitor / Unkown
HY-RS00818 APH1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22392 Aph1b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28916 Aph1b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aph1b NCBI NCBI:83464