Srebf2 - sterol regulatory element binding factor 2 Gene

Mus musculus

Also known as nuc; lop13; SREBP2; bHLHd2; SREBP-2; SREBP2gc

Gene ID: 20788 | Gene type: protein coding

About Srebf2

Summary

Enables DNA-binding transcription factor activity and transcription cis-regulatory region binding activity. Involved in positive regulation of pri-miRNA transcription by RNA polymerase II. Acts upstream of or within Cholesterol homeostasis and positive regulation of transcription by RNA polymerase II. Located in cytoplasm; membrane; and nucleus. Is expressed in several structures, including 1st branchial arch; genitourinary system; limb; nervous system; and retina. Human ortholog(s) of this gene implicated in carotid artery disease; prostate cancer; type 1 diabetes mellitus; type 2 diabetes mellitus; and vascular dementia. Orthologous to human SREBF2 (sterol regulatory element binding transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Srebf2 Products(2)

mRNA	Protein	Name
NM_001411792.1	NP_001398721.1	sterol regulatory element-binding protein 2 isoform 2
NM_033218.2	NP_150087.1	sterol regulatory element-binding protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	11829742	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	11739104	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	33942715	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15102471	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	11739104	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cholesterol homeostasis	IGI IGI: Inferred from genetic interaction	20466882	MGI
involved in positive regulation of cholesterol biosynthetic process	IMP IMP: Inferred from mutant phenotype	33942715	MGI
involved in positive regulation of miRNA transcription	IDA IDA: Inferred from direct assay	23823476	MGI
involved in positive regulation of myelination	IMP IMP: Inferred from mutant phenotype	33942715	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16890542	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12242332	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16100574	MGI
located in membrane	IDA IDA: Inferred from direct assay	11090130	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10397761	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

sterol regulatory element-binding protein 2

sterol regulatory element-binding transcription factor 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13758	SREBF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21946	Srebf2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Srebf2	NCBI	NCBI:6721

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