Spop - speckle-type BTB/POZ protein Gene

Mus musculus

Also known as TEF2; Pcif1

Gene ID: 20747 | Gene type: protein coding

About Spop

Summary

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Acts upstream of or within several processes, including glucose homeostasis; positive regulation of apoptotic process; and regulation of transcription, DNA-templated. Located in nuclear speck. Is expressed in lung; metanephros; and pancreas. Orthologous to human SPOP (speckle type BTB/POZ protein). [provided by Alliance of Genome Resources, Apr 2022]

Spop Products(2)

mRNA	Protein	Name
NM_001359107.1	NP_001346036.1	speckle-type POZ protein
NM_025287.2	NP_079563.2	speckle-type POZ protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	19684112	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15121856	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within glucose homeostasis	IGI IGI: Inferred from genetic interaction	20679732	MGI
acts upstream of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IGI IGI: Inferred from genetic interaction	20811152	MGI
acts upstream of or within negative regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	15121856	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15121856	MGI
acts upstream of or within positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	20811152	MGI
acts upstream of or within positive regulation of type B pancreatic cell apoptotic process	IGI IGI: Inferred from genetic interaction	20679732	MGI
acts upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process	IGI IGI: Inferred from genetic interaction	20811152	MGI
acts upstream of type B pancreatic cell apoptotic process	IGI IGI: Inferred from genetic interaction	20679732	MGI
acts upstream of or within ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	19684112	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nuclear speck	IDA IDA: Inferred from direct assay	15121856	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

speckle-type POZ protein

HIB homolog 1

PDX-1 C-terminal-interacting factor 1

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-136938	NEO2734	Inhibitor	99.63%	Phase 1

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122615	SPOP-IN-6b		99.56%	Unkown
HY-122615B	SPOP-IN-6b dihydrochloride	Inhibitor	99.70%	Unkown
HY-156382	SPOP-IN-1	Inhibitor	99.71%	Unkown
HY-161251	SPOP-IN-2		91.00%	Unkown
HY-122615A	SPOP-IN-6b hydrochloride	Inhibitor	/	Unkown
HY-176035	MS479	Degrader	/	Unkown
HY-176036	MS1262		/	Unkown
HY-RS13700	SPOP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-176038	MS1262-C3-amide-C10-amine		/	Unkown
HY-RS16789	Spop Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23229	Spop Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Spop	NCBI	NCBI:8405

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