Spta1 - spectrin alpha, erythrocytic 1 Gene

Mus musculus

Also known as ha; ihj; sph; nmf4; Spna1; Spna-1

Gene ID: 20739 | Gene type: protein coding

About Spta1

Summary

Predicted to enable actin filament binding activity. Acts upstream of or within several processes, including lymphocyte homeostasis; porphyrin-containing compound biosynthetic process; and positive regulation of T cell proliferation. Located in cuticular plate; membrane; and spectrin-associated Cytoskeleton. Part of spectrin. Is expressed in liver; liver left lobe; and liver right lobe. Used to study hereditary spherocytosis type 1; hereditary spherocytosis type 3; and sickle cell anemia. Human ortholog(s) of this gene implicated in hereditary spherocytosis and hereditary spherocytosis type 3. Orthologous to human SPTA1 (spectrin alpha, erythrocytic 1). [provided by Alliance of Genome Resources, Apr 2022]

Spta1 Products(1)

mRNA	Protein	Name
NM_011465.4	NP_035595.2	spectrin alpha chain, erythrocytic 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20585040	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	8195289	MGI
acts upstream of or within hemopoiesis	IMP IMP: Inferred from mutant phenotype	6841965	MGI
acts upstream of or within lymphocyte homeostasis	IMP IMP: Inferred from mutant phenotype	1934076	MGI
acts upstream of or within plasma membrane organization	IMP IMP: Inferred from mutant phenotype	6841965	MGI
acts upstream of or within porphyrin-containing compound biosynthetic process	IMP IMP: Inferred from mutant phenotype	658175	MGI
acts upstream of or within positive regulation of T cell proliferation	IMP IMP: Inferred from mutant phenotype	7684329	MGI
acts upstream of or within positive regulation of protein binding	IGI IGI: Inferred from genetic interaction	20585040	MGI
acts upstream of or within regulation of cell shape	IMP IMP: Inferred from mutant phenotype	8195289	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cortical cytoskeleton	IDA IDA: Inferred from direct assay	18723693	MGI
located in cuticular plate	IDA IDA: Inferred from direct assay	20016102	MGI
located in membrane	IDA IDA: Inferred from direct assay	18723693	MGI
part of spectrin	IMP IMP: Inferred from mutant phenotype	6234993	MGI
located in spectrin-associated cytoskeleton	IMP IMP: Inferred from mutant phenotype	6234993	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

spectrin alpha chain, erythrocytic 1

alpha-spectrin 1, erythroid	erythroid alpha-spectrin
hemolytic anemia	neuroscience mutagenesis facility, 4
spectrin alpha 1	spectrin alpha chain, erythrocyte
spherocytosis

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13729	SPTA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22829	Spta1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Spta1	NCBI	NCBI:6708

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