Hectd1 - HECT domain E3 ubiquitin protein ligase 1 Gene

Mus musculus

Also known as opm; b2b327Clo; A630086P08Rik

Gene ID: 207304 | Gene type: protein coding

About Hectd1

Summary

Enables ubiquitin protein Ligase activity. Acts upstream of or within several processes, including animal organ development; negative regulation of protein localization to plasma membrane; and protein ubiquitination. Is expressed in several structures, including extraembryonic component; genitourinary system; heart; hemolymphoid system gland; and lung. Orthologous to human HECTD1 (HECT domain E3 ubiquitin protein Ligase 1). [provided by Alliance of Genome Resources, Apr 2022]

Hectd1 Products(8)

mRNA	Protein	Name
NM_001405181.1	NP_001392110.1	E3 ubiquitin-protein ligase HECTD1 isoform 2
NM_001405182.1	NP_001392111.1	E3 ubiquitin-protein ligase HECTD1 isoform 3
NM_001405183.1	NP_001392112.1	E3 ubiquitin-protein ligase HECTD1 isoform 4
NM_001405184.1	NP_001392113.1	E3 ubiquitin-protein ligase HECTD1 isoform 5
NM_001405185.1	NP_001392114.1	E3 ubiquitin-protein ligase HECTD1 isoform 6
NM_001405186.1	NP_001392115.1	E3 ubiquitin-protein ligase HECTD1 isoform 7
NM_001405187.1	NP_001392116.1	E3 ubiquitin-protein ligase HECTD1 isoform 8
NM_144788.3	NP_659037.2	E3 ubiquitin-protein ligase HECTD1 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22431752	MGI
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	22431752	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within aorta development	IMP IMP: Inferred from mutant phenotype	25807483	MGI
acts upstream of or within embryonic placenta development	IMP IMP: Inferred from mutant phenotype	24855001	MGI
acts upstream of or within heart valve development	IMP IMP: Inferred from mutant phenotype	25807483	MGI
acts upstream of or within natural killer cell differentiation	IMP IMP: Inferred from mutant phenotype	24855001	MGI
acts upstream of or within negative regulation of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	22431752	MGI
acts upstream of or within neural tube closure	IMP IMP: Inferred from mutant phenotype	9636176	MGI
involved in neural tube closure	IMP IMP: Inferred from mutant phenotype	17442300	MGI
acts upstream of or within protein K63-linked ubiquitination	IDA IDA: Inferred from direct assay	22431752	MGI
acts upstream of or within protein K63-linked ubiquitination	IMP IMP: Inferred from mutant phenotype	22431752	MGI
acts upstream of or within protein autoubiquitination	IMP IMP: Inferred from mutant phenotype	22431752	MGI
acts upstream of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	22431752	MGI
acts upstream of or within spongiotrophoblast differentiation	IMP IMP: Inferred from mutant phenotype	24855001	MGI
acts upstream of or within trophoblast giant cell differentiation	IMP IMP: Inferred from mutant phenotype	24855001	MGI
acts upstream of or within ventricular septum development	IMP IMP: Inferred from mutant phenotype	25807483	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase HECTD1

HECT domain containing 1	HECT domain-containing protein 1
HECT-type E3 ubiquitin transferase HECTD1	protein open mind

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06107	HECTD1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20554	Hectd1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27063	Hectd1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hectd1	NCBI	NCBI:25831

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