Sox18 - SRY (sex determining region Y)-box 18 Gene

Mus musculus

Also known as Ra; Ragl

Gene ID: 20672 | Gene type: protein coding

About Sox18

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Acts upstream of or within several processes, including circulatory system development; regulation of transcription, DNA-templated; and stem cell fate specification. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; brain; immune system; reproductive system; and urinary system. Human ortholog(s) of this gene implicated in hypotrichosis-lymphedema-telangiectasia syndrome and hypotrichosis-lymphedema-telangiectasia-renal defect syndrome. Orthologous to human SOX18 (SRY-box transcription factor 18). [provided by Alliance of Genome Resources, Apr 2022]

Sox18 Products(1)

mRNA	Protein	Name
NM_009236.2	NP_033262.2	transcription factor SOX-18

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	12446692	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	7651823	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	22344693	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11554755	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	7651823	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	14634005	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within angiogenesis	IGI IGI: Inferred from genetic interaction	16895970	MGI
acts upstream of or within blood vessel development	IMP IMP: Inferred from mutant phenotype	10742113	MGI
acts upstream of or within cell maturation	IDA IDA: Inferred from direct assay	20228271	MGI
acts upstream of or within embryonic heart tube development	IGI IGI: Inferred from genetic interaction	17610846	MGI
acts upstream of or within endocardial cell differentiation	IGI IGI: Inferred from genetic interaction	17610846	MGI
acts upstream of or within endocardium formation	IGI IGI: Inferred from genetic interaction	17610846	MGI
acts upstream of or within hair follicle development	IMP IMP: Inferred from mutant phenotype	10742113	MGI
NOT acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	11094083	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	10742113	MGI
NOT acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	11094083	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	10742113	MGI
acts upstream of or within lymph vessel development	IMP IMP: Inferred from mutant phenotype	291594	MGI
acts upstream of or within lymphangiogenesis	IMP IMP: Inferred from mutant phenotype	18931657	MGI
acts upstream of or within lymphatic endothelial cell differentiation	IMP IMP: Inferred from mutant phenotype	18931657	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	18931657	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	7651823	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11554755	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12446692	MGI
acts upstream of or within regulation of stem cell proliferation	IDA IDA: Inferred from direct assay	20228271	MGI
acts upstream of or within stem cell fate specification	IDA IDA: Inferred from direct assay	20228271	MGI
acts upstream of or within vasculature development	IMP IMP: Inferred from mutant phenotype	19429912	MGI
acts upstream of or within vasculogenesis	IGI IGI: Inferred from genetic interaction	16895970	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	11554755	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	22344693	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transcription factor SOX-18

SRY-box containing gene 18	Sry-related HMG-box gene 18
ragged

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-116940	Sm4	Inhibitor	99.37%	Unkown
HY-RS20494	Sox18 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13590	SOX18 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27002	Sox18 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sox18	NCBI	NCBI:54345

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