Sox11 - SRY (sex determining region Y)-box 11 Gene

Mus musculus

Also known as end1; 1110038H03Rik; 6230403H02Rik

Gene ID: 20666 | Gene type: protein coding

About Sox11

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; nervous system development; and regulation of gene expression. Acts upstream of or within skeletal muscle cell differentiation. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and sensory organ. Used to study Weissenbacher-Zweymuller syndrome. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 9. Orthologous to human SOX11 (SRY-box transcription factor 11). [provided by Alliance of Genome Resources, Apr 2022]

Sox11 Products(1)

mRNA	Protein	Name
NM_009234.6	NP_033260.4	transcription factor SOX-11

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	18403418	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	18505825	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	21527504	MGI
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	19808959	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	18505825	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in closure of optic fissure	IMP IMP: Inferred from mutant phenotype	18423449	MGI
involved in cornea development in camera-type eye	IMP IMP: Inferred from mutant phenotype	18423449	MGI
involved in embryonic digestive tract morphogenesis	IMP IMP: Inferred from mutant phenotype	15254231	MGI
involved in embryonic skeletal system morphogenesis	IMP IMP: Inferred from mutant phenotype	15254231	MGI
involved in eyelid development in camera-type eye	IMP IMP: Inferred from mutant phenotype	15254231	MGI
involved in glial cell development	IMP IMP: Inferred from mutant phenotype	20147379	MGI
involved in glial cell proliferation	IMP IMP: Inferred from mutant phenotype	20147379	MGI
involved in hard palate development	IMP IMP: Inferred from mutant phenotype	15254231	MGI
involved in lens morphogenesis in camera-type eye	IMP IMP: Inferred from mutant phenotype	18423449	MGI
involved in lung morphogenesis	IMP IMP: Inferred from mutant phenotype	15254231	MGI
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	19808959	MGI
involved in negative regulation of glial cell proliferation	IMP IMP: Inferred from mutant phenotype	19808959	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19808959	MGI
involved in nervous system development	IMP IMP: Inferred from mutant phenotype	20596238	MGI
involved in neuroepithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	20646169	MGI
involved in noradrenergic neuron differentiation	IMP IMP: Inferred from mutant phenotype	20147379	MGI
involved in outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	15254231	MGI
involved in positive regulation of BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	18423449	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	21527504	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	18423449	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	19808959	MGI
involved in positive regulation of hippo signaling	IMP IMP: Inferred from mutant phenotype	20596238	MGI
involved in positive regulation of hormone secretion	IMP IMP: Inferred from mutant phenotype	21527504	MGI
involved in positive regulation of lens epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	18423449	MGI
involved in positive regulation of neurogenesis	IDA IDA: Inferred from direct assay	19490090	MGI
involved in positive regulation of neuron differentiation	IDA IDA: Inferred from direct assay	19490090	MGI
involved in positive regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	19808959	MGI
involved in positive regulation of ossification	IMP IMP: Inferred from mutant phenotype	15254231	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18403418	MGI
acts upstream of or within skeletal muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	20847309	MGI
involved in soft palate development	IMP IMP: Inferred from mutant phenotype	15254231	MGI
involved in spinal cord development	IMP IMP: Inferred from mutant phenotype	20646169	MGI
involved in sympathetic nervous system development	IMP IMP: Inferred from mutant phenotype	20147379	MGI
involved in ventricular septum morphogenesis	IMP IMP: Inferred from mutant phenotype	15254231	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	15456859	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transcription factor SOX-11

SRY-box containing gene 11

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13584	SOX11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21764	Sox11 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sox11	NCBI	NCBI:6664

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