Sod2 - superoxide dismutase 2, mitochondrial Gene

Mus musculus

Also known as MnSOD; Sod-2

Gene ID: 20656 | Gene type: protein coding

About Sod2

Summary

Enables superoxide dismutase activity. Acts upstream of or within several processes, including animal organ development; apoptotic signaling pathway; and regulation of cellular biosynthetic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Used to study Canavan disease; Leigh disease; amyotrophic lateral sclerosis type 1; congestive heart failure; and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); lipid storage disease (multiple); liver disease (multiple); and optic nerve disease (multiple). Orthologous to human SOD2 (superoxide dismutase 2). [provided by Alliance of Genome Resources, Apr 2022]

Sod2 Products(1)

mRNA	Protein	Name
NM_013671.3	NP_038699.2	superoxide dismutase [Mn], mitochondrial precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables oxidoreductase activity	IMP IMP: Inferred from mutant phenotype	15205258	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	21909133	MGI
enables superoxide dismutase activity	IDA IDA: Inferred from direct assay	7333654	MGI
enables superoxide dismutase activity	IMP IMP: Inferred from mutant phenotype	12176043	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IMP IMP: Inferred from mutant phenotype	16873728	MGI
acts upstream of or within apoptotic mitochondrial changes	IMP IMP: Inferred from mutant phenotype	11226230	MGI
acts upstream of or within detection of oxygen	IMP IMP: Inferred from mutant phenotype	11156968	MGI
acts upstream of or within erythrophore differentiation	IMP IMP: Inferred from mutant phenotype	15205258	MGI
acts upstream of or within glutathione metabolic process	IMP IMP: Inferred from mutant phenotype	10049502	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	7493016	MGI
acts upstream of or within hemopoiesis	IMP IMP: Inferred from mutant phenotype	8790408	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage	IMP IMP: Inferred from mutant phenotype	15642323	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to oxidative stress	IMP IMP: Inferred from mutant phenotype	15642323	MGI
acts upstream of or within liver development	IMP IMP: Inferred from mutant phenotype	17367743	MGI
acts upstream of or within locomotory behavior	IMP IMP: Inferred from mutant phenotype	8790408	MGI
acts upstream of or within mitochondrion organization	IMP IMP: Inferred from mutant phenotype	8790408	MGI
acts upstream of or within multicellular organismal-level iron ion homeostasis	IMP IMP: Inferred from mutant phenotype	15205258	MGI
acts upstream of or within negative regulation of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	16219542	MGI
acts upstream of or within negative regulation of fibroblast proliferation	IDA IDA: Inferred from direct assay	18218638	MGI
acts upstream of or within neuron development	IMP IMP: Inferred from mutant phenotype	8790408	MGI
acts upstream of or within positive regulation of nitric oxide biosynthetic process	IMP IMP: Inferred from mutant phenotype	15637112	MGI
acts upstream of or within post-embryonic development	IMP IMP: Inferred from mutant phenotype	7493016	MGI
acts upstream of or within regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	17023572	MGI
acts upstream of or within regulation of catalytic activity	IMP IMP: Inferred from mutant phenotype	9927656	MGI
acts upstream of or within regulation of mitochondrial membrane potential	IMP IMP: Inferred from mutant phenotype	17367743	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17670746	MGI
acts upstream of or within release of cytochrome c from mitochondria	IMP IMP: Inferred from mutant phenotype	10212301	MGI
acts upstream of or within removal of superoxide radicals	IMP IMP: Inferred from mutant phenotype	16873728	MGI
acts upstream of or within respiratory electron transport chain	IMP IMP: Inferred from mutant phenotype	11226230	MGI
acts upstream of or within response to activity	IMP IMP: Inferred from mutant phenotype	15781740	MGI
acts upstream of or within response to axon injury	IMP IMP: Inferred from mutant phenotype	16677818	MGI
acts upstream of or within response to gamma radiation	IGI IGI: Inferred from genetic interaction	15182862	MGI
acts upstream of or within response to hydrogen peroxide	IMP IMP: Inferred from mutant phenotype	15642323	MGI
acts upstream of or within response to hyperoxia	IMP IMP: Inferred from mutant phenotype	11796207	MGI
acts upstream of or within response to oxidative stress	IGI IGI: Inferred from genetic interaction	15182862	MGI
acts upstream of or within response to oxidative stress	IMP IMP: Inferred from mutant phenotype	15182862	MGI
acts upstream of or within response to reactive oxygen species	IMP IMP: Inferred from mutant phenotype	9462746	MGI
acts upstream of or within response to superoxide	IMP IMP: Inferred from mutant phenotype	11156968	MGI
NOT acts upstream of or within sensory perception of sound	IMP IMP: Inferred from mutant phenotype	16843623	MGI
acts upstream of or within superoxide anion generation	IMP IMP: Inferred from mutant phenotype	10212301	MGI
acts upstream of or within superoxide metabolic process	IMP IMP: Inferred from mutant phenotype	10049502	MGI
acts upstream of or within vasodilation	IMP IMP: Inferred from mutant phenotype	15637112	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	11583975	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

superoxide dismutase [Mn], mitochondrial

manganese SOD

manganese superoxide dismutase

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-134476	NF-κΒ activator 1	Activator	99.59%	Unkown
HY-134477	NF-κΒ activator 2	Activator	99.76%	Unkown
HY-W014940	Ethylene glycol dimethacrylate		99.52%	Unkown
HY-158162	SIRT3 activator 1	Activator	98.14%	Unkown
HY-RS13560	SOD2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16939	Sod2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23382	Sod2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sod2	NCBI	NCBI:6648

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