Sod1 - superoxide dismutase 1, soluble Gene

Mus musculus

Also known as Ipo1; SODC; Ipo-1; Sod-1; CuZnSOD; Cu/Zn-SOD; B430204E11Rik

Gene ID: 20655 | Gene type: protein coding

About Sod1

Summary

Enables superoxide dismutase activity. Involved in axonal transport; negative regulation of inflammatory response; and positive regulation of phagocytosis. Acts upstream of or within several processes, including hydrogen peroxide biosynthetic process; muscle cell cellular homeostasis; and neurogenesis. Located in extracellular space. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study amyotrophic lateral sclerosis type 1; dry eye syndrome; and low tension glaucoma. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; artery disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); and neurodegenerative disease (multiple). Orthologous to human SOD1 (superoxide dismutase 1). [provided by Alliance of Genome Resources, Apr 2022]

Sod1 Products(1)

mRNA	Protein	Name
NM_011434.2	NP_035564.1	superoxide dismutase [Cu-Zn]

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	2960971	MGI
enables superoxide dismutase activity	IDA IDA: Inferred from direct assay	291939	MGI
enables superoxide dismutase activity	IMP IMP: Inferred from mutant phenotype	8673102	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within action potential initiation	IMP IMP: Inferred from mutant phenotype	30952836	MGI
involved in anterograde axonal transport	IMP IMP: Inferred from mutant phenotype	20510358	MGI
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	16036348	MGI
acts upstream of or within auditory receptor cell stereocilium organization	IMP IMP: Inferred from mutant phenotype	10464373	MGI
acts upstream of or within determination of adult lifespan	IMP IMP: Inferred from mutant phenotype	16377630	MGI
acts upstream of ectopic germ cell programmed cell death	IMP IMP: Inferred from mutant phenotype	16036348	MGI
acts upstream of or within embryo implantation	IMP IMP: Inferred from mutant phenotype	9516486	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	30952836	MGI
acts upstream of or within glutathione metabolic process	IMP IMP: Inferred from mutant phenotype	16377630	MGI
acts upstream of or within heart contraction	IMP IMP: Inferred from mutant phenotype	10679476	MGI
acts upstream of or within hydrogen peroxide biosynthetic process	IMP IMP: Inferred from mutant phenotype	14679182	MGI
acts upstream of or within intracellular iron ion homeostasis	IMP IMP: Inferred from mutant phenotype	16377630	MGI
acts upstream of or within locomotory behavior	IMP IMP: Inferred from mutant phenotype	10433959	MGI
acts upstream of or within muscle cell cellular homeostasis	IMP IMP: Inferred from mutant phenotype	16716900	MGI
acts upstream of or within myeloid cell homeostasis	IGI IGI: Inferred from genetic interaction	11493445	MGI
acts upstream of or within myeloid cell homeostasis	IMP IMP: Inferred from mutant phenotype	11493445	MGI
acts upstream of or within negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	12223545	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16036348	MGI
acts upstream of or within negative regulation of developmental process	IMP IMP: Inferred from mutant phenotype	16036348	MGI
involved in negative regulation of inflammatory response	IGI IGI: Inferred from genetic interaction	25381879	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	10464373	MGI
acts upstream of or within negative regulation of reproductive process	IMP IMP: Inferred from mutant phenotype	16036348	MGI
acts upstream of or within neurofilament cytoskeleton organization	IGI IGI: Inferred from genetic interaction	11343650	MGI
acts upstream of or within neurofilament cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	11343650	MGI
acts upstream of or within neuronal action potential	IMP IMP: Inferred from mutant phenotype	30952836	MGI
acts upstream of or within ovarian follicle development	IMP IMP: Inferred from mutant phenotype	9724058	MGI
acts upstream of or within peripheral nervous system myelin maintenance	IMP IMP: Inferred from mutant phenotype	10433959	MGI
acts upstream of or within positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	12223545	MGI
involved in positive regulation of phagocytosis	IGI IGI: Inferred from genetic interaction	25381879	MGI
acts upstream of or within regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	12433839	MGI
acts upstream of or within regulation of multicellular organism growth	IMP IMP: Inferred from mutant phenotype	16377630	MGI
acts upstream of or within relaxation of vascular associated smooth muscle	IMP IMP: Inferred from mutant phenotype	12433839	MGI
acts upstream of or within removal of superoxide radicals	IGI IGI: Inferred from genetic interaction	11493445	MGI
acts upstream of or within removal of superoxide radicals	IMP IMP: Inferred from mutant phenotype	8673102	MGI
acts upstream of or within response to axon injury	IMP IMP: Inferred from mutant phenotype	8673102	MGI
acts upstream of or within response to ethanol	IMP IMP: Inferred from mutant phenotype	17448893	MGI
acts upstream of or within response to heat	IMP IMP: Inferred from mutant phenotype	16942767	MGI
acts upstream of or within response to hydrogen peroxide	IMP IMP: Inferred from mutant phenotype	15642323	MGI
acts upstream of or within response to oxidative stress	IDA IDA: Inferred from direct assay	12223545	MGI
acts upstream of or within response to oxidative stress	IMP IMP: Inferred from mutant phenotype	16716900	MGI
acts upstream of or within response to reactive oxygen species	IMP IMP: Inferred from mutant phenotype	17059387	MGI
acts upstream of or within response to superoxide	IMP IMP: Inferred from mutant phenotype	9516486	MGI
acts upstream of or within response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	16831125	MGI
acts upstream of or within retina homeostasis	IMP IMP: Inferred from mutant phenotype	16844785	MGI
involved in retrograde axonal transport	IMP IMP: Inferred from mutant phenotype	20510358	MGI
acts upstream of or within sensory perception of sound	IMP IMP: Inferred from mutant phenotype	10436316	MGI
acts upstream of or within spermatogenesis	IMP IMP: Inferred from mutant phenotype	16036348	MGI
acts upstream of or within superoxide anion generation	IDA IDA: Inferred from direct assay	15317809	MGI
acts upstream of or within superoxide metabolic process	IMP IMP: Inferred from mutant phenotype	11404260	MGI
acts upstream of or within transmission of nerve impulse	IMP IMP: Inferred from mutant phenotype	10433959	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	15634772	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

superoxide dismutase [Cu-Zn]

Cu(2+)-Zn2+ superoxide dismutase

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-132580	Tofersen		96.53%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-16074	ATN-224		≥98.0%	Phase 2

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-115445	LCS-1		99.81%	Unkown
HY-W115718	Cuprizone		99.61%	Unkown
HY-132580A	Tofersen sodium		97.19%	Unkown
HY-153019	NUCC-0000323	Inhibitor	99.85%	Unkown
HY-138131	SOD1-Derlin-1 inhibitor-1	Inhibitor	99.93%	Unkown
HY-123982	SOD1-Derlin-1 inhibitor-2	Inhibitor	99.86%	Unkown
HY-148901	CMB-087229	Inhibitor	98.05%	Unkown
HY-RS13559	SOD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-145294	ROCK2-IN-5	Inhibitor	/	Unkown
HY-163772	Fraxinellone analog 1	Activator	/	Unkown
HY-172152	MP-010		/	Unkown
HY-173025	Nurr1 agonist 12	Agonist	/	Unkown
HY-E70377	Cu/Zn Superoxide dismutase		/	Unkown
HY-P10627	SOD1 (147-153) human		/	Unkown
HY-RS16926	Sod1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23369	Sod1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sod1	NCBI	NCBI:6647

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