Snai2 - snail family zinc finger 2 Gene

Mus musculus

Also known as Slug; Slugh; Snail2

Gene ID: 20583 | Gene type: protein coding

About Snai2

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and chromatin binding activity. Involved in several processes, including desmosome disassembly; mesenchyme development; and sensory perception of sound. Acts upstream of or within several processes, including animal organ morphogenesis; negative regulation of cell adhesion involved in substrate-bound cell migration; and negative regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; embryo mesenchyme; and genitourinary system. Used to study Waardenburg syndrome type 2D. Human ortholog(s) of this gene implicated in Waardenburg syndrome type 2D and piebaldism. Orthologous to human SNAI2 (snail family transcriptional repressor 2). [provided by Alliance of Genome Resources, Apr 2022]

Snai2 Products(1)

mRNA	Protein	Name
NM_011415.3	NP_035545.1	zinc finger protein SNAI2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	18223155	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	18663143	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IGI IGI: Inferred from genetic interaction	16286009	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	17905753	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	18331720	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cartilage morphogenesis	IGI IGI: Inferred from genetic interaction	17376812	MGI
involved in cell migration involved in endocardial cushion formation	IMP IMP: Inferred from mutant phenotype	18663143	MGI
acts upstream of or within cellular response to ionizing radiation	IGI IGI: Inferred from genetic interaction	16286009	MGI
acts upstream of or within positive effect chromatin organization	IMP IMP: Inferred from mutant phenotype	17905753	MGI
involved in desmosome disassembly	IMP IMP: Inferred from mutant phenotype	9182671	MGI
acts upstream of or within endothelial cell migration	IMP IMP: Inferred from mutant phenotype	18663143	MGI
acts upstream of or within epithelial cell migration	IGI IGI: Inferred from genetic interaction	17376812	MGI
acts upstream of or within epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	17916597	MGI
involved in epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	9182671	MGI
acts upstream of or within epithelial to mesenchymal transition involved in endocardial cushion formation	IMP IMP: Inferred from mutant phenotype	18663143	MGI
involved in epithelial to mesenchymal transition involved in endocardial cushion formation	IMP IMP: Inferred from mutant phenotype	18663143	MGI
involved in epithelium development	IMP IMP: Inferred from mutant phenotype	18716062	MGI
acts upstream of hematopoietic stem cell proliferation	IMP IMP: Inferred from mutant phenotype	20032500	MGI
acts upstream of myeloid cell apoptotic process	IGI IGI: Inferred from genetic interaction	16286009	MGI
acts upstream of or within negative regulation of cell adhesion involved in substrate-bound cell migration	IMP IMP: Inferred from mutant phenotype	18663143	MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IDA IDA: Inferred from direct assay	10518215	MGI
involved in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IDA IDA: Inferred from direct assay	10518215	MGI
acts upstream of or within negative regulation of hematopoietic stem cell proliferation	IMP IMP: Inferred from mutant phenotype	20032500	MGI
acts upstream of or within negative regulation of myeloid cell apoptotic process	IGI IGI: Inferred from genetic interaction	16286009	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18223155	MGI
involved in pigmentation	IMP IMP: Inferred from mutant phenotype	12444107	MGI
acts upstream of or within positive regulation of fat cell differentiation	IGI IGI: Inferred from genetic interaction	17905753	MGI
acts upstream of or within positive regulation of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	17905753	MGI
acts upstream of or within regulation of branching involved in salivary gland morphogenesis	IMP IMP: Inferred from mutant phenotype	20671187	MGI
acts upstream of or within response to radiation	IDA IDA: Inferred from direct assay	12833143	MGI
acts upstream of or within response to radiation	IMP IMP: Inferred from mutant phenotype	12833143	MGI
acts upstream of or within roof of mouth development	IGI IGI: Inferred from genetic interaction	17376812	MGI
acts upstream of or within roof of mouth development	IMP IMP: Inferred from mutant phenotype	17376812	MGI
involved in sensory perception of sound	IMP IMP: Inferred from mutant phenotype	12444107	MGI
acts upstream of or within substrate-dependent cell migration	IMP IMP: Inferred from mutant phenotype	18663143	MGI
acts upstream of white fat cell differentiation	IGI IGI: Inferred from genetic interaction	17905753	MGI
acts upstream of white fat cell differentiation	IMP IMP: Inferred from mutant phenotype	17905753	MGI
acts upstream of or within white fat cell differentiation	IMP IMP: Inferred from mutant phenotype	17905753	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	20046880	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12833143	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

zinc finger protein SNAI2

neural crest transcription factor Slug	protein snail homolog 2
slug, chicken homolog

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-147041	Selvigaltin	Inhibitor	98.87%	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13471	SNAI2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS16305	Snai2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26608	Snai2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Snai2	NCBI	NCBI:6591

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