2. Gene
  3. Slit3 - slit guidance ligand 3 Gene

Slit3 - slit guidance ligand 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Slil2; Slit1; b2b2362.1Clo

Gene ID: 20564 | Gene type: protein coding

About Slit3

Summary

Predicted to enable Roundabout binding activity and heparin binding activity. Involved in aortic valve morphogenesis; atrioventricular valve morphogenesis; and ventricular septum morphogenesis. Acts upstream of or within several processes, including axon guidance; negative regulation of cell population proliferation; and negative regulation of gene expression. Located in extracellular space. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; heart; and sensory organ. Used to study congenital diaphragmatic hernia. Orthologous to human SLIT3 (slit guidance ligand 3). [provided by Alliance of Genome Resources, Apr 2022]

Slit3 Products(1)

mRNA Protein Name
NM_011412.3 NP_035542.2 slit homolog 3 protein precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within animal organ morphogenesis IGI
IGI: Inferred from genetic interaction
15091338 MGI
acts upstream of or within animal organ morphogenesis IMP
IMP: Inferred from mutant phenotype
14550534 MGI
involved in aortic valve morphogenesis IMP
IMP: Inferred from mutant phenotype
25691540 MGI
involved in atrioventricular valve morphogenesis IMP
IMP: Inferred from mutant phenotype
25691540 MGI
acts upstream of or within axon guidance IDA
IDA: Inferred from direct assay
12954717 MGI
acts upstream of or within negative regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
18829537 MGI
acts upstream of or within negative regulation of gene expression IGI
IGI: Inferred from genetic interaction
18829537 MGI
involved in ventricular septum morphogenesis IMP
IMP: Inferred from mutant phenotype
25691540 MGI
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
12954717 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

slit homolog 3 protein

slit-3

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13370 SLIT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13372 SLIT3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20490 Slit3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26998 Slit3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slit3 NCBI NCBI:6586