Slc6a2 - solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Gene

Mus musculus

Also known as NET; NE-T; Slc6a5

Gene ID: 20538 | Gene type: protein coding

About Slc6a2

Summary

Enables monoamine transmembrane transporter activity and neurotransmitter transmembrane transporter activity. Involved in neurotransmitter reuptake and norepinephrine uptake. Acts upstream of or within neurotransmitter transport and response to pain. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in neuron projection; neuronal cell body membrane; and presynaptic membrane. Predicted to be integral component of plasma membrane. Is expressed in adrenal gland; lip; nervous system; sensory organ; and testis. Used to study heart conduction disease. Human ortholog(s) of this gene implicated in hypertension and neurocirculatory asthenia. Orthologous to human SLC6A2 (solute carrier family 6 member 2). [provided by Alliance of Genome Resources, Apr 2022]

Slc6a2 Products(1)

mRNA	Protein	Name
NM_009209.3	NP_033235.3	sodium-dependent noradrenaline transporter

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables monoamine transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	20858707	MGI
enables neurotransmitter transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	20858707	MGI
enables norepinephrine:sodium symporter activity	IDA IDA: Inferred from direct assay	16269905	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in neurotransmitter reuptake	IDA IDA: Inferred from direct assay	10769386	MGI
involved in neurotransmitter reuptake	IMP IMP: Inferred from mutant phenotype	10769386	MGI
acts upstream of or within neurotransmitter transport	IDA IDA: Inferred from direct assay	11805341	MGI
involved in neurotransmitter transport	IMP IMP: Inferred from mutant phenotype	20858707	MGI
involved in norepinephrine uptake	IMP IMP: Inferred from mutant phenotype	20858707	MGI
acts upstream of or within response to pain	IMP IMP: Inferred from mutant phenotype	11805341	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

sodium-dependent noradrenaline transporter

NE transporter	norepinephrine transporter
solute carrier family 6 member 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13306	SLC6A2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20194	Slc6a2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26699	Slc6a2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc6a2	NCBI	NCBI:6530

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