2. Gene
  3. Slc4a1 - solute carrier family 4 (anion exchanger), member 1 Gene

Slc4a1 - solute carrier family 4 (anion exchanger), member 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Ae1; CD233; Empb3; l11Jus51

Gene ID: 20533 | Gene type: protein coding

About Slc4a1

Summary

Enables anion transmembrane transporter activity; ankyrin binding activity; and Hemoglobin binding activity. Involved in chloride transport. Acts upstream of or within several processes, including bicarbonate transport; erythrocyte development; and negative regulation of glycolytic process through fructose-6-phosphate. Located in basolateral plasma membrane; cortical cytoskeleton; and cytoplasmic side of plasma membrane. Is expressed in several structures, including blood; blood vessel; liver; lung; and metanephros. Used to study hereditary spherocytosis type 4 and renal tubular acidosis. Human ortholog(s) of this gene implicated in congenital hemolytic anemia; hereditary spherocytosis; hereditary spherocytosis type 4; malaria; and renal tubular acidosis. Orthologous to human SLC4A1 (solute carrier family 4 member 1 (Diego blood group)). [provided by Alliance of Genome Resources, Apr 2022]

Slc4a1 Products(1)

mRNA Protein Name
NM_011403.2 NP_035533.1 band 3 anion transport protein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ankyrin binding IPI
IPI: Inferred from physical interaction
17715300 MGI
enables bicarbonate transmembrane transporter activity IDA
IDA: Inferred from direct assay
23878365 MGI
enables chloride transmembrane transporter activity IDA
IDA: Inferred from direct assay
17690150 MGI
enables chloride:bicarbonate antiporter activity IMP
IMP: Inferred from mutant phenotype
17409310 MGI
enables hemoglobin binding IDA
IDA: Inferred from direct assay
22452706 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11591653 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within bicarbonate transport IDA
IDA: Inferred from direct assay
23878365 MGI
acts upstream of or within blood coagulation IMP
IMP: Inferred from mutant phenotype
9716609 MGI
involved in chloride transport IDA
IDA: Inferred from direct assay
17690150 MGI
acts upstream of or within erythrocyte development IMP
IMP: Inferred from mutant phenotype
17715300 MGI
acts upstream of or within negative regulation of glycolytic process through fructose-6-phosphate IMP
IMP: Inferred from mutant phenotype
18698006 MGI
acts upstream of or within negative regulation of oxidoreductase activity IMP
IMP: Inferred from mutant phenotype
18698006 MGI
acts upstream of or within negative regulation of urine volume IMP
IMP: Inferred from mutant phenotype
17409310 MGI
acts upstream of or within pH elevation IMP
IMP: Inferred from mutant phenotype
17409310 MGI
acts upstream of or within plasma membrane phospholipid scrambling IMP
IMP: Inferred from mutant phenotype
9716609 MGI
acts upstream of or within protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
18698006 MGI
Cellular Component GO Annotation Evidence Reference Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
12388412 MGI
located in cortical cytoskeleton IDA
IDA: Inferred from direct assay
18723693 MGI
located in cytoplasmic side of plasma membrane IDA
IDA: Inferred from direct assay
17715300 MGI
located in membrane IDA
IDA: Inferred from direct assay
17690150 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
23878365 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

band 3 anion transport protein

AE 1

MEB3

anion exchange protein 1

anion exchanger 1

erythrocyte membrane protein band 3

solute carrier family 4 member 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13265 SLC4A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20193 Slc4a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26698 Slc4a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc4a1 NCBI NCBI:6521