Slc31a1 - solute carrier family 31, member 1 Gene

Mus musculus

Also known as Ctr1; 4930445G01Rik

Gene ID: 20529 | Gene type: protein coding

About Slc31a1

Summary

Enables copper ion transmembrane transporter activity. Acts upstream of or within cellular copper ion homeostasis and copper ion import. Located in late endosome; plasma membrane; and recycling endosome. Is expressed in several structures, including adrenal gland; alimentary system; early embryo; nervous system; and nose. Orthologous to human SLC31A1 (solute carrier family 31 member 1). [provided by Alliance of Genome Resources, Apr 2022]

Slc31a1 Products(1)

mRNA	Protein	Name
NM_175090.4	NP_780299.2	high affinity copper uptake protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables copper ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	11391005	MGI
enables copper ion transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	12177073	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	24167251	MGI
enables silver ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	20569931	MGI
enables xenobiotic transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	12370430	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in angiogenesis	IMP IMP: Inferred from mutant phenotype	35027734	MGI
involved in copper ion import	IDA IDA: Inferred from direct assay	16950140	MGI
acts upstream of or within copper ion import	IMP IMP: Inferred from mutant phenotype	12177073	MGI
involved in copper ion import	IMP IMP: Inferred from mutant phenotype	16847145	MGI
involved in copper ion transport	IDA IDA: Inferred from direct assay	11391005	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	12177073	MGI
acts upstream of or within intracellular copper ion homeostasis	IGI IGI: Inferred from genetic interaction	24167251	MGI
involved in silver ion transmembrane transport	IDA IDA: Inferred from direct assay	20569931	MGI
involved in xenobiotic transport	IMP IMP: Inferred from mutant phenotype	12370430	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	16950140	MGI
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	19144690	MGI
located in intercalated disc	IDA IDA: Inferred from direct assay	28973536	MGI
located in late endosome	IDA IDA: Inferred from direct assay	24167251	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	28973536	MGI
located in recycling endosome	IDA IDA: Inferred from direct assay	24167251	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

high affinity copper uptake protein 1

copper transporter 1

solute carrier family 13 (sodium/sulphate symporters), member 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13188	SLC31A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17281	Slc31a1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23736	Slc31a1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc31a1	NCBI	NCBI:1317

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