Slc22a5 - solute carrier family 22 (organic cation transporter), member 5 Gene

Mus musculus

Also known as jvs; Lstpl; Octn2

Gene ID: 20520 | Gene type: protein coding

About Slc22a5

Summary

Enables (R)-carnitine transmembrane transporter activity. Involved in (R)-carnitine transmembrane transport and transport across blood-brain barrier. Acts upstream of or within several processes, including adult heart development; carnitine metabolic process; and carnitine transport. Located in brush border membrane. Is expressed in several structures, including liver; metanephros; nasal cavity mucosa; spleen; and testis. Used to study systemic primary carnitine deficiency disease. Human ortholog(s) of this gene implicated in Crohn's disease; cardiomyopathy; inherited metabolic disorder; and systemic primary carnitine deficiency disease. Orthologous to human SLC22A5 (solute carrier family 22 member 5). [provided by Alliance of Genome Resources, Apr 2022]

Slc22a5 Products(3)

mRNA	Protein	Name
NM_001362711.1	NP_001349640.1	solute carrier family 22 member 5 isoform 2
NM_001362712.1	NP_001349641.1	solute carrier family 22 member 5 isoform 2
NM_011396.3	NP_035526.1	solute carrier family 22 member 5 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables (R)-carnitine transmembrane transporter activity	IDA IDA: Inferred from direct assay	20722056	MGI
enables (R)-carnitine transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	14595704	MGI
enables carnitine transmembrane transporter activity	IDA IDA: Inferred from direct assay	10454528	MGI
enables carnitine transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	9634010	MGI
enables quaternary ammonium group transmembrane transporter activity	IDA IDA: Inferred from direct assay	11010964	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in (R)-carnitine transmembrane transport	IDA IDA: Inferred from direct assay	10454528	MGI
involved in (R)-carnitine transmembrane transport	IMP IMP: Inferred from mutant phenotype	14595704	MGI
involved in (R)-carnitine transport	IDA IDA: Inferred from direct assay	20722056	MGI
acts upstream of or within adult heart development	IMP IMP: Inferred from mutant phenotype	9140816	MGI
acts upstream of or within carnitine metabolic process	IMP IMP: Inferred from mutant phenotype	1996978	MGI
acts upstream of or within carnitine transport	IDA IDA: Inferred from direct assay	11010964	MGI
acts upstream of or within carnitine transport	IMP IMP: Inferred from mutant phenotype	8155735	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	8670273	MGI
acts upstream of or within locomotory behavior	IMP IMP: Inferred from mutant phenotype	17027329	MGI
acts upstream of or within mitochondrion organization	IMP IMP: Inferred from mutant phenotype	7773507	MGI
acts upstream of or within quaternary ammonium group transport	IDA IDA: Inferred from direct assay	11010964	MGI
acts upstream of or within reproductive structure development	IMP IMP: Inferred from mutant phenotype	10100867	MGI
involved in response to tumor necrosis factor	IDA IDA: Inferred from direct assay	20722056	MGI
involved in response to type II interferon	IDA IDA: Inferred from direct assay	20722056	MGI
involved in transport across blood-brain barrier	IMP IMP: Inferred from mutant phenotype	14595704	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	20722056	MGI
located in brush border membrane	IDA IDA: Inferred from direct assay	15523054	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

solute carrier family 22 member 5

high-affinity sodium-dependent carnitine cotransporter	juvenile visceral steatosis
organic cation/carnitine transporter 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13077	SLC22A5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20645	Slc22a5 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27155	Slc22a5 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc22a5	NCBI	NCBI:6584

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