NLRP11 - NLR family pyrin domain containing 11 Gene

Homo sapiens

Also known as NOD17; PAN10; NALP11; PYPAF6; PYPAF7; CLR19.6

Gene ID: 204801 | Gene type: protein coding

About NLRP11

Cytogenetic location: 19q13.42-q13.43 Genomic coordinates (GRCh38): 19:55,785,399-55,836,575 (from NCBI)

This gene has 6 transcripts (splice variants), 36 orthologues and 20 paralogues. Low expression observed in reference dataset.

Summary

This gene is a member of the the NOD-like Receptor protein (NLRP) gene family and encodes a protein with an N-terminal pyrin death (PYD) domain and nucleoside triphosphate hydrolase (NACHT) domain and a C-terminal leucine-rich repeats (LRR) region. This gene has been shown to regulate caspases in the proinflammatory signal transduction pathway and, based on studies of Other members of the NLRP gene family with similar domain structure, is predicted to form part of the multiprotein inflammasome complex. Alternative splicing produces multiple transcript variants encoding distince isoforms. [provided by RefSeq, May 2017]

NLRP11 Products(5)

mRNA	Protein	Name
NM_001297743.3	NP_001284672.1	NACHT, LRR and PYD domains-containing protein 11 isoform 2
NM_001385451.2	NP_001372380.1	NACHT, LRR and PYD domains-containing protein 11 isoform 3
NM_001385453.2	NP_001372382.1	NACHT, LRR and PYD domains-containing protein 11 isoform 4
NM_001394894.2	NP_001381823.1	NACHT, LRR and PYD domains-containing protein 11 isoform 1
NM_145007.5	NP_659444.2	NACHT, LRR and PYD domains-containing protein 11 isoform 1

NLRP11 Protein Structure

PYRIN

NACHT

0
200
400
600
800
1033 a.a.

Protein Preferred Names

Protein Names

NACHT, LRR and PYD domains-containing protein 11

NACHT, leucine rich repeat and PYD containing 11

Related Diseases

Diseases

Alias

Petrositis

Acute Petrositis	Chronic Petrositis
Inflammation Of Petrous Bone	Osteitis Of Petrous Bone
Osteomyelitis Of Petrous Bone

Premature Menopause

Primary Ovarian Insufficiency	Premature Ovarian Failure
Hypergonadotropic Hypogonadism	Premature Ovarian Insufficiency
Menopause - Premature	Menopause Praecox
Menopause Premature	Menopause, Premature
Female Hypergonadotropic Hypogonadism	Hypergonadotrophic Ovarian Failure
Primary Female Hypogonadism	Pof - [Premature Ovarian Failure]
Ovarian Failure	Ovarian Secretion Suppression
Ovary Hyposecretion	Ovary Secretion Deficiency
Premature Menopause Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09351	NLRP11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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