Six4 - sine oculis-related homeobox 4 Gene

Mus musculus

Also known as AREC3; TrexBF

Gene ID: 20474 | Gene type: protein coding

About Six4

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; positive regulation of morphogenesis of an epithelium; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including embryonic organ morphogenesis; myoblast migration; and thymus development. Located in cytoplasm and nucleus. Is expressed in several structures, including exocrine gland; nervous system; sensory organ; tongue; and urinary system. Orthologous to human SIX4 (SIX homeobox 4). [provided by Alliance of Genome Resources, Apr 2022]

Six4 Products(3)

mRNA	Protein	Name
NM_001362272.2	NP_001349201.1	homeobox protein SIX4 isoform 2
NM_001409898.1	NP_001396827.1	homeobox protein SIX4 isoform 3
NM_011382.3	NP_035512.1	homeobox protein SIX4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	14966291	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15955062	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	14966291	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15955062	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12215533	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8814301	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within anatomical structure development	IGI IGI: Inferred from genetic interaction	16530750	MGI
acts upstream of or within embryonic cranial skeleton morphogenesis	IGI IGI: Inferred from genetic interaction	20515681	MGI
acts upstream of or within embryonic skeletal system morphogenesis	IGI IGI: Inferred from genetic interaction	15788460	MGI
involved in fungiform papilla morphogenesis	IMP IMP: Inferred from mutant phenotype	21978088	MGI
involved in generation of neurons	IMP IMP: Inferred from mutant phenotype	16938278	MGI
acts upstream of or within inner ear morphogenesis	IGI IGI: Inferred from genetic interaction	15788460	MGI
involved in male gonad development	IMP IMP: Inferred from mutant phenotype	23987514	MGI
involved in male sex determination	IMP IMP: Inferred from mutant phenotype	23987514	MGI
involved in male sex differentiation	IMP IMP: Inferred from mutant phenotype	23987514	MGI
involved in metanephric mesenchyme development	IMP IMP: Inferred from mutant phenotype	17300925	MGI
acts upstream of or within myoblast migration	IGI IGI: Inferred from genetic interaction	15788460	MGI
involved in myotome development	IMP IMP: Inferred from mutant phenotype	15788460	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15955062	MGI
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	15788460	MGI
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	16938278	MGI
involved in negative regulation of satellite cell differentiation	IMP IMP: Inferred from mutant phenotype	20696153	MGI
involved in olfactory placode formation	IMP IMP: Inferred from mutant phenotype	19027001	MGI
involved in pharyngeal system development	IMP IMP: Inferred from mutant phenotype	16530750	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	14966291	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15955062	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	17300925	MGI
involved in positive regulation of branching involved in ureteric bud morphogenesis	IMP IMP: Inferred from mutant phenotype	17300925	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15955062	MGI
involved in positive regulation of ureteric bud formation	IMP IMP: Inferred from mutant phenotype	17300925	MGI
involved in protein localization to nucleus	IDA IDA: Inferred from direct assay	10490620	MGI
involved in regulation of branch elongation involved in ureteric bud branching	IMP IMP: Inferred from mutant phenotype	17300925	MGI
involved in regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	19027001	MGI
acts upstream of or within regulation of gene expression	IGI IGI: Inferred from genetic interaction	21884692	MGI
acts upstream of or within regulation of protein localization	IGI IGI: Inferred from genetic interaction	21884692	MGI
acts upstream of or within regulation of synaptic assembly at neuromuscular junction	IGI IGI: Inferred from genetic interaction	21884692	MGI
involved in sarcomere organization	IMP IMP: Inferred from mutant phenotype	21884692	MGI
involved in skeletal muscle fiber differentiation	IMP IMP: Inferred from mutant phenotype	21884692	MGI
acts upstream of or within skeletal muscle tissue development	IGI IGI: Inferred from genetic interaction	15788460	MGI
involved in skeletal muscle tissue development	IMP IMP: Inferred from mutant phenotype	17592144	MGI
acts upstream of or within thymus development	IGI IGI: Inferred from genetic interaction	16530750	MGI
involved in tongue development	IMP IMP: Inferred from mutant phenotype	21978088	MGI
involved in trigeminal ganglion development	IMP IMP: Inferred from mutant phenotype	16938278	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	9990334	MGI
located in nucleus	IDA IDA: Inferred from direct assay	8814301	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

homeobox protein SIX4

sine oculis-related homeobox 4 homolog

skeletal muscle-specific ARE-binding protein AREC3

Six4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Six4	Q61321	Kdm6a	Mus musculus	O70546	Anti Bait CoIP	20300060

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12961	SIX4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21434	Six4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Six4	NCBI	NCBI:51804

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