2. Gene
  3. Siah2 - siah E3 ubiquitin protein ligase 2 Gene

Siah2 - siah E3 ubiquitin protein ligase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Sinh2

Gene ID: 20439 | Gene type: protein coding

About Siah2

Summary

Enables ubiquitin protein Ligase activity. Involved in regulation of circadian rhythm and ubiquitin-dependent protein catabolic process. Predicted to be located in several cellular components, including early endosome; neuronal cell body; and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including brain; cranium; gonad; hemolymphoid system gland; and sensory organ. Orthologous to human SIAH2 (siah E3 ubiquitin protein Ligase 2). [provided by Alliance of Genome Resources, Apr 2022]

Siah2 Products(1)

mRNA Protein Name
NM_009174.3 NP_033200.2 E3 ubiquitin-protein ligase SIAH2
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
18323779 MGI
enables ubiquitin protein ligase activity IMP
IMP: Inferred from mutant phenotype
26392558 MGI
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
26070566 MGI
Biological Process GO Annotation Evidence Reference Source
involved in regulation of circadian rhythm IMP
IMP: Inferred from mutant phenotype
26392558 MGI
involved in ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
26070566 MGI
involved in ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
26392558 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase SIAH2

RING-type E3 ubiquitin transferase SIAH2

mSiah2

seven in absentia 2

seven in absentia homolog 2

siah-2

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12892 SIAH2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21046 Siah2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27564 Siah2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Siah2 NCBI NCBI:6478