2. Gene
  3. Sh2d1a - SH2 domain containing 1A Gene

Sh2d1a - SH2 domain containing 1A Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as SAP; Gm686

Gene ID: 20400 | Gene type: protein coding

About Sh2d1a

Summary

Acts upstream of or within humoral immune response and positive regulation of natural killer cell mediated cytotoxicity. Predicted to be located in cytoplasm. Is expressed in retina. Used to study X-linked lymphoproliferative syndrome 1. Human ortholog(s) of this gene implicated in X-linked lymphoproliferative syndrome 1. Orthologous to human SH2D1A (SH2 domain containing 1A). [provided by Alliance of Genome Resources, Apr 2022]

Sh2d1a Products(4)

mRNA Protein Name
NM_001313688.1 NP_001300617.1 SH2 domain-containing protein 1A isoform 1
NM_001313689.1 NP_001300618.1 SH2 domain-containing protein 1A isoform 3
NM_001313691.1 NP_001300620.1 SH2 domain-containing protein 1A isoform 4
NM_011364.4 NP_035494.1 SH2 domain-containing protein 1A isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
10970095 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within humoral immune response IMP
IMP: Inferred from mutant phenotype
12529646 MGI
acts upstream of natural killer cell mediated cytotoxicity IGI
IGI: Inferred from genetic interaction
19648922 MGI
acts upstream of natural killer cell mediated cytotoxicity IMP
IMP: Inferred from mutant phenotype
16127454 MGI
acts upstream of or within positive regulation of natural killer cell mediated cytotoxicity IGI
IGI: Inferred from genetic interaction
19648922 MGI
acts upstream of or within positive regulation of natural killer cell mediated cytotoxicity IMP
IMP: Inferred from mutant phenotype
16127454 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

SH2 domain-containing protein 1A

Duncan disease homolog

SH2 domain protein 1A

T-cell signal transduction molecule SAP

signaling lymphocytic activation molecule-associated protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12821 SH2D1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21930 Sh2d1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28446 Sh2d1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sh2d1a NCBI NCBI:4068