Sgpl1 - sphingosine phosphate lyase 1 Gene

Mus musculus

Also known as Spl; S1PL; D10Xrf456

Gene ID: 20397 | Gene type: protein coding

About Sgpl1

Summary

Predicted to enable sphinganine-1-phosphate aldolase activity. Acts upstream of or within several processes, including animal organ development; cellular hormone metabolic process; and face morphogenesis. Located in endoplasmic reticulum. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in nephrotic syndrome type 14. Orthologous to human SGPL1 (sphingosine-1-phosphate lyase 1). [provided by Alliance of Genome Resources, Apr 2022]

Sgpl1 Products(3)

mRNA	Protein	Name
NM_001316673.1	NP_001303602.1	sphingosine-1-phosphate lyase 1
NM_001316674.1	NP_001303603.1	sphingosine-1-phosphate lyase 1
NM_009163.4	NP_033189.2	sphingosine-1-phosphate lyase 1

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Leydig cell differentiation	IMP IMP: Inferred from mutant phenotype	19056881	MGI
acts upstream of or within androgen metabolic process	IMP IMP: Inferred from mutant phenotype	19056881	MGI
acts upstream of or within estrogen metabolic process	IMP IMP: Inferred from mutant phenotype	19056881	MGI
acts upstream of or within excretion	IMP IMP: Inferred from mutant phenotype	17143286	MGI
acts upstream of or within face morphogenesis	IMP IMP: Inferred from mutant phenotype	17143286	MGI
acts upstream of or within female gonad development	IMP IMP: Inferred from mutant phenotype	19056881	MGI
acts upstream of or within fibroblast migration	IMP IMP: Inferred from mutant phenotype	17143286	MGI
acts upstream of or within hemopoiesis	IMP IMP: Inferred from mutant phenotype	17143286	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	17143286	MGI
acts upstream of or within luteinization	IMP IMP: Inferred from mutant phenotype	19056881	MGI
acts upstream of or within platelet-derived growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17143286	MGI
acts upstream of or within post-embryonic development	IMP IMP: Inferred from mutant phenotype	17143286	MGI
acts upstream of or within regulation of multicellular organism growth	IMP IMP: Inferred from mutant phenotype	17143286	MGI
acts upstream of or within roof of mouth development	IMP IMP: Inferred from mutant phenotype	17143286	MGI
acts upstream of or within skeletal system morphogenesis	IMP IMP: Inferred from mutant phenotype	17143286	MGI
acts upstream of or within spermatogenesis	IMP IMP: Inferred from mutant phenotype	19056881	MGI
acts upstream of or within vasculogenesis	IMP IMP: Inferred from mutant phenotype	17143286	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	28165339	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

sphingosine-1-phosphate lyase 1

SP-lyase 1	SPL 1
sphingosine-1-phosphate aldolase

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12809	SGPL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-D2284	SGPL1 fluorogenic substrate		/	Unkown
HY-RS21755	Sgpl1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sgpl1	NCBI	NCBI:8879

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