Sema6a - sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A Gene

Mus musculus

Also known as VIa; Semaq; Sema6A-1; A730020P05Rik

Gene ID: 20358 | Gene type: protein coding

About Sema6a

Summary

Enables identical protein binding activity; semaphorin receptor binding activity; and transmembrane signaling receptor activity. Involved in generation of neurons; positive regulation of neuron migration; and semaphorin-plexin signaling pathway. Acts upstream of or within cell surface receptor signaling pathway and centrosome localization. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; limb mesenchyme; nervous system; and sensory organ. Orthologous to human SEMA6A (semaphorin 6A). [provided by Alliance of Genome Resources, Apr 2022]

Sema6a Products(2)

mRNA	Protein	Name
NM_001311097.1	NP_001298026.1	semaphorin-6A isoform 2 precursor
NM_018744.2	NP_061214.2	semaphorin-6A isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	20877282	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10993894	MGI
enables semaphorin receptor binding	IGI IGI: Inferred from genetic interaction	18327254	MGI
enables semaphorin receptor binding	IPI IPI: Inferred from physical interaction	15814794	MGI
enables transmembrane signaling receptor activity	IMP IMP: Inferred from mutant phenotype	20877282	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in axon guidance	IMP IMP: Inferred from mutant phenotype	16205717	MGI
acts upstream of or within cell surface receptor signaling pathway	IDA IDA: Inferred from direct assay	18327254	MGI
acts upstream of or within centrosome localization	IMP IMP: Inferred from mutant phenotype	18327254	MGI
involved in neuron migration	IMP IMP: Inferred from mutant phenotype	16205717	MGI
involved in positive regulation of neuron migration	IMP IMP: Inferred from mutant phenotype	20877282	MGI
involved in semaphorin-plexin signaling pathway	IMP IMP: Inferred from mutant phenotype	20877282	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	20877282	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

semaphorin-6A

Mutant line 997	sema Q
sema VIA	semaphorin Q
semaphorin VIA	semaphorin-6A-1

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12665	SEMA6A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21192	Sema6a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sema6a	NCBI	NCBI:57556

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