Sema3f - sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F Gene

Mus musculus

Also known as Sema4; Semak

Gene ID: 20350 | Gene type: protein coding

About Sema3f

Summary

Enables chemorepellent activity. Involved in nervous system development; regulation of postsynapse organization; and ventral trunk neural crest cell migration. Acts upstream of or within generation of neurons; negative chemotaxis; and neural crest cell migration. Located in extracellular space. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human SEMA3F (semaphorin 3F). [provided by Alliance of Genome Resources, Apr 2022]

Sema3f Products(6)

mRNA	Protein	Name
NM_001311151.3	NP_001298080.1	semaphorin-3F isoform 1 precursor
NM_001379496.2	NP_001366425.1	semaphorin-3F isoform 2 precursor
NM_001405023.1	NP_001391952.1	semaphorin-3F isoform 4 precursor
NM_001405024.1	NP_001391953.1	semaphorin-3F isoform 5 precursor
NM_001405025.2	NP_001391954.1	semaphorin-3F isoform 1 precursor
NM_011349.4	NP_035479.2	semaphorin-3F isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chemorepellent activity	IDA IDA: Inferred from direct assay	11683995	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of axon extension involved in axon guidance	IDA IDA: Inferred from direct assay	9753685	MGI
acts upstream of axon extension involved in axon guidance	IGI IGI: Inferred from genetic interaction	11683995	MGI
involved in axon extension involved in axon guidance	IMP IMP: Inferred from mutant phenotype	22790009	MGI
acts upstream of or within axon guidance	IDA IDA: Inferred from direct assay	12435358	MGI
involved in branchiomotor neuron axon guidance	IMP IMP: Inferred from mutant phenotype	18804103	MGI
involved in facial nerve structural organization	IMP IMP: Inferred from mutant phenotype	18804103	MGI
acts upstream of or within negative chemotaxis	IDA IDA: Inferred from direct assay	16319111	MGI
acts upstream of or within negative chemotaxis	IGI IGI: Inferred from genetic interaction	11683995	MGI
acts upstream of or within negative regulation of axon extension involved in axon guidance	IDA IDA: Inferred from direct assay	9753685	MGI
acts upstream of or within negative regulation of axon extension involved in axon guidance	IGI IGI: Inferred from genetic interaction	11683995	MGI
involved in nerve development	IMP IMP: Inferred from mutant phenotype	22790009	MGI
involved in neural crest cell migration involved in autonomic nervous system development	IMP IMP: Inferred from mutant phenotype	19386662	MGI
involved in regulation of postsynapse organization	IDA IDA: Inferred from direct assay	20010807	MGI
involved in regulation of postsynapse organization	IMP IMP: Inferred from mutant phenotype	20010807	MGI
involved in semaphorin-plexin signaling pathway	IMP IMP: Inferred from mutant phenotype	18804103	MGI
involved in sympathetic ganglion development	IMP IMP: Inferred from mutant phenotype	22790009	MGI
involved in sympathetic neuron projection extension	IMP IMP: Inferred from mutant phenotype	22790009	MGI
involved in sympathetic neuron projection guidance	IMP IMP: Inferred from mutant phenotype	22790009	MGI
involved in trigeminal nerve structural organization	IMP IMP: Inferred from mutant phenotype	18804103	MGI
acts upstream of or within trunk neural crest cell migration	IMP IMP: Inferred from mutant phenotype	16319111	MGI
involved in ventral trunk neural crest cell migration	IMP IMP: Inferred from mutant phenotype	19386662	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	20010807	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	20010807	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

semaphorin-3F

semaphorin IV

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12655	SEMA3F Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20594	Sema3f Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27102	Sema3f Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sema3f	NCBI	NCBI:6405

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