Sema3c - sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C Gene

Mus musculus

Also known as SemE; Semae; 1110036B02Rik

Gene ID: 20348 | Gene type: protein coding

About Sema3c

Summary

Enables semaphorin receptor binding activity. Involved in several processes, including cardiac endothelial to mesenchymal transition; outflow tract septum morphogenesis; and positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis. Acts upstream of or within several processes, including chordate embryonic development; circulatory system development; and dichotomous subdivision of terminal units involved in salivary gland branching. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Orthologous to human SEMA3C (semaphorin 3C). [provided by Alliance of Genome Resources, Apr 2022]

Sema3c Products(1)

mRNA	Protein	Name
NM_013657.5	NP_038685.3	semaphorin-3C precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables semaphorin receptor binding	IPI IPI: Inferred from physical interaction	15239958	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in axon guidance	IDA IDA: Inferred from direct assay	17021275	MGI
acts upstream of or within blood vessel remodeling	IMP IMP: Inferred from mutant phenotype	11688556	MGI
involved in cardiac endothelial to mesenchymal transition	IDA IDA: Inferred from direct assay	26053665	MGI
involved in cardiac right ventricle morphogenesis	IEP IEP: Inferred from expression pattern	19666519	MGI
acts upstream of or within dichotomous subdivision of terminal units involved in salivary gland branching	IDA IDA: Inferred from direct assay	17626059	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	11688556	MGI
involved in limb bud formation	IEP IEP: Inferred from expression pattern	19666519	MGI
acts upstream of or within neural crest cell migration	IMP IMP: Inferred from mutant phenotype	11688556	MGI
involved in neural tube development	IEP IEP: Inferred from expression pattern	19666519	MGI
involved in outflow tract morphogenesis	IEP IEP: Inferred from expression pattern	19666519	MGI
involved in outflow tract septum morphogenesis	IGI IGI: Inferred from genetic interaction	26053665	MGI
involved in outflow tract septum morphogenesis	IMP IMP: Inferred from mutant phenotype	26053665	MGI
involved in positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis	IDA IDA: Inferred from direct assay	26053665	MGI
acts upstream of or within post-embryonic development	IMP IMP: Inferred from mutant phenotype	11688556	MGI
involved in pulmonary myocardium development	IEP IEP: Inferred from expression pattern	19666519	MGI
involved in semaphorin-plexin signaling pathway	IMP IMP: Inferred from mutant phenotype	26053665	MGI
involved in somitogenesis	IEP IEP: Inferred from expression pattern	19666519	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	15239958	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

semaphorin-3C

sema E

semaphorin E

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12652	SEMA3C Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19812	Sema3c Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26308	Sema3c Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sema3c	NCBI	NCBI:10512

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