Sct - secretin Gene

Mus musculus

Gene ID: 20287 | Gene type: protein coding

About Sct

Summary

This gene encodes the precursor of a gastrointestinal peptide hormone of the secretin-glucagon family. The encoded protein is secreted as a prohormone that undergoes proteolytic processing to generate a mature peptide hormone. The mature peptide regulates secretion of gastric acid, biocarbonate ions from pancreatic and biliary duct epithelia and water homeostasis in the gastrointestinal system. Mice lacking the encoded protein display decreased survival of neuroprogenitor cells during early postnatal period and impaired long-term potentiation and spatial learning in adulthood. Alternative splicing results in multiple transcript variants encoding different isoforms. All of these isoforms may be processed in a similar manner to generate the mature peptide hormone. [provided by RefSeq, Jul 2015]

Sct Products(3)

mRNA	Protein	Name
NM_001287171.1	NP_001274100.1	secretin isoform 1 precursor
NM_001309439.1	NP_001296368.1	secretin isoform 3 precursor
NM_011328.3	NP_035458.1	secretin isoform 2 preproprotein

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	30449620	MGI
acts upstream of or within dentate gyrus development	IMP IMP: Inferred from mutant phenotype	21159798	MGI
involved in diet induced thermogenesis	IDA IDA: Inferred from direct assay	30449620	MGI
involved in hippocampus development	IMP IMP: Inferred from mutant phenotype	18534766	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	21159798	MGI
acts upstream of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	21159798	MGI
acts upstream of or within neuronal stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	21159798	MGI
involved in positive regulation of lipid catabolic process	IDA IDA: Inferred from direct assay	30449620	MGI
involved in positive regulation of lipid catabolic process	IMP IMP: Inferred from mutant phenotype	24273196	MGI
involved in regulation of appetite	IDA IDA: Inferred from direct assay	30449620	MGI
involved in regulation of appetite	IMP IMP: Inferred from mutant phenotype	20927047	MGI
involved in regulation of synaptic plasticity	IMP IMP: Inferred from mutant phenotype	18534766	MGI
involved in response to nutrient levels	IDA IDA: Inferred from direct assay	30449620	MGI
acts upstream of or within visual learning	IMP IMP: Inferred from mutant phenotype	21159798	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

secretin

Related Agents

Clinical Phase

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99769	Omfiloctocog alfa		97.10%	Phase 4
HY-P99952	Ripertamab	Inhibitor	/	Phase 3
HY-P99619	Finotonlimab	Inhibitor	/	Phase 3

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-162269	Nampt activator-5	Activator	/	Unkown
HY-RS12567	SCT Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19113	Sct Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25603	Sct Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sct	NCBI	NCBI:6343

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