Atxn1 - ataxin 1 Gene

Mus musculus

Also known as Atx1; Sca1; Gm10786; 2900016G23Rik

Gene ID: 20238 | Gene type: protein coding

About Atxn1

Summary

Enables RNA binding activity and chromatin binding activity. Involved in brain development; learning or memory; and social behavior. Acts upstream of or within several processes, including negative regulation of insulin-like growth factor receptor signaling pathway; regulation of transcription by RNA polymerase II; and visual learning. Located in nuclear inclusion body. Part of protein-containing complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; liver; and skeleton. Used to study spinocerebellar ataxia type 1. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 1. Orthologous to human ATXN1 (ataxin 1). [provided by Alliance of Genome Resources, Apr 2022]

Atxn1 Products(3)

mRNA	Protein	Name
NM_001199304.1	NP_001186233.1	ataxin-1 isoform b
NM_001199305.1	NP_001186234.1	ataxin-1 isoform a
NM_009124.6	NP_033150.2	ataxin-1 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables POZ domain binding	IPI IPI: Inferred from physical interaction	37261953	MGI
enables RNA binding	IDA IDA: Inferred from direct assay	15615787	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	20628574	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17110330	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within adult locomotory behavior	IMP IMP: Inferred from mutant phenotype	9651231	MGI
involved in brain development	IMP IMP: Inferred from mutant phenotype	28288114	MGI
acts upstream of or within excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	9651231	MGI
acts upstream of insulin-like growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18216249	MGI
involved in learning	IMP IMP: Inferred from mutant phenotype	28288114	MGI
acts upstream of or within lung alveolus development	IGI IGI: Inferred from genetic interaction	22014525	MGI
involved in memory	IMP IMP: Inferred from mutant phenotype	28288114	MGI
acts upstream of or within negative regulation of insulin-like growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18216249	MGI
acts upstream of or within negative regulation of phosphorylation	IMP IMP: Inferred from mutant phenotype	18216249	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	22014525	MGI
acts upstream of phosphorylation	IMP IMP: Inferred from mutant phenotype	18216249	MGI
acts upstream of or within positive regulation of glial cell proliferation	IMP IMP: Inferred from mutant phenotype	20531390	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18216249	MGI
involved in social behavior	IMP IMP: Inferred from mutant phenotype	28288114	MGI
acts upstream of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	22014525	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18216249	MGI
acts upstream of or within visual learning	IMP IMP: Inferred from mutant phenotype	9651231	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nuclear inclusion body	IDA IDA: Inferred from direct assay	15615787	MGI
located in nucleus	IDA IDA: Inferred from direct assay	20531390	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	18337722	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ataxin-1

spinocerebellar ataxia 1 homolog

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-173353	ATXN1-MED15 PPI-IN-1		/	Unkown
HY-RS01253	ATXN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01255	ATXN1L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21490	Atxn1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Atxn1	NCBI	NCBI:6310

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