Ryr2 - ryanodine receptor 2, cardiac Gene

Mus musculus

Also known as RYR-2; 9330127I20Rik

Gene ID: 20191 | Gene type: protein coding

About Ryr2

Summary

Enables several functions, including Calmodulin binding activity; identical protein binding activity; and ryanodine-sensitive calcium-release channel activity. Involved in several processes, including cellular response to organonitrogen compound; regulation of heart contraction; and release of sequestered calcium ion into cytosol by sarcoplasmic reticulum. Acts upstream of or within several processes, including calcium ion transport; left ventricular cardiac muscle tissue morphogenesis; and response to caffeine. Located in Z disc; sarcoplasmic reticulum membrane; and smooth endoplasmic reticulum. Part of Calcium Channel complex. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and respiratory system. Used to study arrhythmogenic right ventricular dysplasia 2; catecholaminergic polymorphic ventricular tachycardia 1; and heart disease. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy; arrhythmogenic right ventricular dysplasia 2; and catecholaminergic polymorphic ventricular tachycardia 1. Orthologous to human RYR2 (ryanodine receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Ryr2 Products(1)

mRNA	Protein	Name
NM_023868.2	NP_076357.2	ryanodine receptor 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium channel activity	IDA IDA: Inferred from direct assay	9628868	MGI
enables calmodulin binding	IDA IDA: Inferred from direct assay	17431507	MGI
enables enzyme binding	IPI IPI: Inferred from physical interaction	16213210	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	12324472	MGI
enables intracellularly gated calcium channel activity	IDA IDA: Inferred from direct assay	10473538	MGI
enables organic cyclic compound binding	IPI IPI: Inferred from physical interaction	17431507	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16352659	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	12676814	MGI
enables ryanodine-sensitive calcium-release channel activity	IDA IDA: Inferred from direct assay	14593104	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in Purkinje myocyte to ventricular cardiac muscle cell signaling	IMP IMP: Inferred from mutant phenotype	17872467	MGI
acts upstream of or within calcium ion transmembrane import into cytosol	IMP IMP: Inferred from mutant phenotype	17431507	MGI
acts upstream of or within calcium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	21673970	MGI
acts upstream of or within calcium ion transport	IDA IDA: Inferred from direct assay	14593104	MGI
involved in calcium ion transport	IDA IDA: Inferred from direct assay	10473538	MGI
involved in calcium ion transport	IMP IMP: Inferred from mutant phenotype	9628868	MGI
acts upstream of or within calcium ion transport	IPI IPI: Inferred from physical interaction	16204356	MGI
involved in calcium-mediated signaling	IMP IMP: Inferred from mutant phenotype	9628868	MGI
acts upstream of or within cardiac muscle hypertrophy	IMP IMP: Inferred from mutant phenotype	17431507	MGI
acts upstream of or within cellular response to caffeine	IDA IDA: Inferred from direct assay	12089338	MGI
involved in cellular response to caffeine	IDA IDA: Inferred from direct assay	9628868	MGI
involved in cellular response to epinephrine stimulus	IMP IMP: Inferred from mutant phenotype	17872467	MGI
involved in embryonic heart tube morphogenesis	IMP IMP: Inferred from mutant phenotype	9628868	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	12089338	MGI
involved in intracellular calcium ion homeostasis	IMP IMP: Inferred from mutant phenotype	9628868	MGI
acts upstream of or within left ventricular cardiac muscle tissue morphogenesis	IMP IMP: Inferred from mutant phenotype	17431507	MGI
acts upstream of or within positive regulation of heart rate	IMP IMP: Inferred from mutant phenotype	12089338	MGI
involved in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	IGI IGI: Inferred from genetic interaction	12837242	MGI
involved in regulation of heart rate	IMP IMP: Inferred from mutant phenotype	17872467	MGI
involved in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IDA IDA: Inferred from direct assay	20226167	MGI
acts upstream of or within release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IMP IMP: Inferred from mutant phenotype	12089338	MGI
acts upstream of or within response to caffeine	IDA IDA: Inferred from direct assay	14593104	MGI
involved in response to caffeine	IDA IDA: Inferred from direct assay	10473538	MGI
involved in response to hypoxia	IDA IDA: Inferred from direct assay	19120137	MGI
involved in type B pancreatic cell apoptotic process	IMP IMP: Inferred from mutant phenotype	15044459	MGI
involved in ventricular cardiac muscle cell action potential	IMP IMP: Inferred from mutant phenotype	17872467	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in Z disc	IDA IDA: Inferred from direct assay	16204356	MGI
part of calcium channel complex	IDA IDA: Inferred from direct assay	16213210	MGI
located in membrane	IDA IDA: Inferred from direct assay	17431507	MGI
located in sarcomere	IDA IDA: Inferred from direct assay	20226167	MGI
located in sarcoplasmic reticulum	IDA IDA: Inferred from direct assay	12919952	MGI
located in sarcoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	14592808	MGI
located in smooth endoplasmic reticulum	IDA IDA: Inferred from direct assay	23454728	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ryanodine receptor 2

calcium release channel	cardiac muscle ryanodine receptor
cardiac muscle ryanodine receptor-calcium release channel	ryanodine receptor type 2
type 2 ryanodine receptor

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W010950	Flecainide	Inhibitor	99.98%	Unkown
HY-W010950A	Flecainide hydrochloride	Inhibitor	99.93%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-119850	Aladorian	Inhibitor	99.83%	Phase 2

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-149662	TMDJ-035	Inhibitor	99.92%	Unkown
HY-15292	S107	Ligand	99.77%	Unkown
HY-N7491A	Ent-(+)-Verticilide	Inhibitor	99.91%	Unkown
HY-P5114A	Maurocalcine TFA	Agonist	95.19%	Unkown
HY-RS12369	RYR2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-103059	SOICR-IN-1		99.62%	Unkown
HY-P5114	Maurocalcine	Agonist	/	Unkown
HY-Z7733	O-Desmethylcarvedilol	Inhibitor	97.4%	Unkown
HY-119850A	Aladorian sodium	Inhibitor	/	Unkown
HY-P5319	MCaE12A		/	Unkown
HY-149779	RyR2 stabilizer-1	Modulator	/	Unkown
HY-166478S	O-Desmethyl carvedilol-d5	Inhibitor	/	Unkown
HY-RS19951	Ryr2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26453	Ryr2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W010950S	Flecainide-d3		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ryr2	NCBI	NCBI:6262

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