Ryk - receptor-like tyrosine kinase Gene

Mus musculus

Also known as Vik; ERK-3

Gene ID: 20187 | Gene type: protein coding

About Ryk

Summary

Enables Wnt-activated receptor activity; Wnt-protein binding activity; and Frizzled binding activity. Involved in nervous system development. Acts upstream of or within generation of neurons; negative chemotaxis; and skeletal system morphogenesis. Located in cytoplasm; nucleus; and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human RYK (receptor like tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Ryk Products(3)

mRNA	Protein	Name
NM_001042607.1	NP_001036072.1	tyrosine-protein kinase RYK isoform 2 precursor
NM_001284258.1	NP_001271187.1	tyrosine-protein kinase RYK isoform 3
NM_013649.3	NP_038677.3	tyrosine-protein kinase RYK isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Wnt receptor activity	IPI IPI: Inferred from physical interaction	15454084	MGI
enables Wnt-protein binding	IPI IPI: Inferred from physical interaction	15454084	MGI
enables frizzled binding	IPI IPI: Inferred from physical interaction	15454084	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10932185	MGI
NOT enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	1334548	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in Wnt signaling pathway	IDA IDA: Inferred from direct assay	15454084	MGI
acts upstream of or within Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	16723543	MGI
acts upstream of axon extension involved in axon guidance	IGI IGI: Inferred from genetic interaction	16723543	MGI
involved in axon guidance	IDA IDA: Inferred from direct assay	16116452	MGI
involved in axon guidance	IMP IMP: Inferred from mutant phenotype	16723543	MGI
acts upstream of or within axonogenesis	IGI IGI: Inferred from genetic interaction	15454084	MGI
involved in chemorepulsion of dopaminergic neuron axon	IGI IGI: Inferred from genetic interaction	23517308	MGI
acts upstream of or within commissural neuron axon guidance	IMP IMP: Inferred from mutant phenotype	16723543	MGI
involved in corpus callosum development	IMP IMP: Inferred from mutant phenotype	16723543	MGI
involved in midbrain dopaminergic neuron differentiation	IMP IMP: Inferred from mutant phenotype	23517308	MGI
acts upstream of or within negative chemotaxis	IGI IGI: Inferred from genetic interaction	16723543	MGI
acts upstream of or within negative regulation of axon extension involved in axon guidance	IGI IGI: Inferred from genetic interaction	16723543	MGI
involved in neuron differentiation	IDA IDA: Inferred from direct assay	19000841	MGI
involved in neuron projection development	IMP IMP: Inferred from mutant phenotype	15454084	MGI
acts upstream of or within skeletal system morphogenesis	IMP IMP: Inferred from mutant phenotype	10932185	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19000841	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	34407949	MGI
located in membrane	IDA IDA: Inferred from direct assay	8394755	MGI
located in nucleus	IDA IDA: Inferred from direct assay	19000841	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	7822791	MGI
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	34407949	MGI
is active in presynaptic active zone membrane	IDA IDA: Inferred from direct assay	34407949	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

tyrosine-protein kinase RYK

NYK-R	growth factor receptor
kinase VIK	met-related kinase

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12367	RYK Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18743	Ryk Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25230	Ryk Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ryk	NCBI	NCBI:6259

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