Ncor1 - nuclear receptor co-repressor 1 Gene

Mus musculus

Also known as N-CoR; RIP13; Rxrip13; mKIAA1047; 5730405M06Rik; A230020K14Rik

Gene ID: 20185 | Gene type: protein coding

About Ncor1

Summary

Enables several functions, including histone deacetylase regulator activity; nuclear receptor binding activity; and transcription corepressor activity. Involved in locomotor rhythm. Acts upstream of or within several processes, including hemopoiesis; regulation of gene expression; and regulation of signal transduction. Located in cytoplasm and nucleus. Part of transcription repressor complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human NCOR1 (nuclear receptor corepressor 1). [provided by Alliance of Genome Resources, Apr 2022]

Ncor1 Products(3)

mRNA	Protein	Name
NM_001252313.1	NP_001239242.1	nuclear receptor corepressor 1 isoform 1
NM_011308.3	NP_035438.3	nuclear receptor corepressor 1 isoform 2
NM_177229.3	NP_796203.1	nuclear receptor corepressor 1 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	14980219	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	17392792	MGI
enables histone deacetylase regulator activity	IDA IDA: Inferred from direct assay	19037247	MGI
enables histone deacetylase regulator activity	IMP IMP: Inferred from mutant phenotype	15695367	MGI
enables nuclear retinoic acid receptor binding	IDA IDA: Inferred from direct assay	8961273	MGI
enables nuclear retinoid X receptor binding	IDA IDA: Inferred from direct assay	7760852	MGI
enables nuclear thyroid hormone receptor binding	IDA IDA: Inferred from direct assay	8961273	MGI
enables nuclear thyroid hormone receptor binding	IPI IPI: Inferred from physical interaction	19052228	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9139821	MGI
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	15175761	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17928865	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	16127449	MGI
enables transcription corepressor activity	IGI IGI: Inferred from genetic interaction	7566114	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	IMP IMP: Inferred from mutant phenotype	11030619	MGI
acts upstream of or within T cell differentiation in thymus	IMP IMP: Inferred from mutant phenotype	11030619	MGI
acts upstream of or within cellular response to Thyroglobulin triiodothyronine	IGI IGI: Inferred from genetic interaction	24550004	MGI
acts upstream of or within cholesterol homeostasis	IMP IMP: Inferred from mutant phenotype	19052228	MGI
acts upstream of or within circadian regulation of gene expression	IGI IGI: Inferred from genetic interaction	19037247	MGI
acts upstream of or within definitive erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	11030619	MGI
involved in epidermis development	IGI IGI: Inferred from genetic interaction	32467224	MGI
involved in establishment of skin barrier	IGI IGI: Inferred from genetic interaction	32467224	MGI
involved in gene expression	IGI IGI: Inferred from genetic interaction	32467224	MGI
involved in in utero embryonic development	IGI IGI: Inferred from genetic interaction	32467224	MGI
involved in locomotor rhythm	IMP IMP: Inferred from mutant phenotype	19037247	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15695367	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	15681609	MGI
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	24794873	MGI
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	17606624	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	7566114	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	11328825	MGI
involved in protein stabilization	IGI IGI: Inferred from genetic interaction	32467224	MGI
acts upstream of or within regulation of multicellular organism growth	IGI IGI: Inferred from genetic interaction	19037247	MGI
acts upstream of or within regulation of thyroid hormone receptor signaling pathway	IGI IGI: Inferred from genetic interaction	24550004	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	19052228	MGI
acts upstream of or within thalamus development	IMP IMP: Inferred from mutant phenotype	11030619	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17606624	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11092755	MGI
part of transcription regulator complex	IPI IPI: Inferred from physical interaction	17182846	MGI
part of transcription repressor complex	IPI IPI: Inferred from physical interaction	17182846	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

nuclear receptor corepressor 1

N-CoR1

retinoid X receptor-interacting protein 13

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-121900	LT175	Agonist	99.79%	Unkown
HY-RS09096	NCOR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20452	Ncor1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26961	Ncor1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ncor1	NCBI	NCBI:9611

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