Rxra - retinoid X receptor alpha Gene

Mus musculus

Also known as Nr2b1; RXRalpha1; 9530071D11Rik

Gene ID: 20181 | Gene type: protein coding

About Rxra

Summary

Enables DNA binding activity and DNA-binding transcription factor activity. Contributes to nuclear receptor activity and transcription cis-regulatory region binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including animal organ development; regulation of branching involved in prostate gland morphogenesis; and regulation of cellular macromolecule biosynthetic process. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; liver; and sensory organ. Used to study congenital heart disease; dilated cardiomyopathy; and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in pancreatic Cancer. Orthologous to human RXRA (retinoid X receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]

Rxra Products(3)

mRNA	Protein	Name
NM_001290481.1	NP_001277410.1	retinoic acid receptor RXR-alpha isoform 2
NM_001290482.1	NP_001277411.1	retinoic acid receptor RXR-alpha isoform 2
NM_011305.3	NP_035435.1	retinoic acid receptor RXR-alpha isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	15601870	MGI
enables DNA-binding transcription factor activity	IGI IGI: Inferred from genetic interaction	7760852	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15319426	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IPI IPI: Inferred from physical interaction	15681609	MGI
enables RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12015306	MGI
enables chromatin DNA binding	IDA IDA: Inferred from direct assay	17952069	MGI
contributes to nuclear receptor activity	IDA IDA: Inferred from direct assay	17107947	MGI
enables nuclear receptor activity	IDA IDA: Inferred from direct assay	1312497	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8598193	MGI
enables sequence-specific DNA binding	IGI IGI: Inferred from genetic interaction	7823919	MGI
contributes to transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	17107947	MGI
enables transcription coactivator binding	IPI IPI: Inferred from physical interaction	17641689	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within camera-type eye development	IGI IGI: Inferred from genetic interaction	9376317	MGI
acts upstream of or within cardiac muscle cell proliferation	IGI IGI: Inferred from genetic interaction	9428411	MGI
acts upstream of or within cardiac muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	9428411	MGI
acts upstream of or within embryo implantation	IGI IGI: Inferred from genetic interaction	9892670	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	29431742	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	9550726	MGI
acts upstream of or within in utero embryonic development	IGI IGI: Inferred from genetic interaction	9892670	MGI
involved in mRNA transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	1312497	MGI
acts upstream of or within maternal placenta development	IGI IGI: Inferred from genetic interaction	9892670	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	22001906	MGI
acts upstream of or within placenta development	IMP IMP: Inferred from mutant phenotype	9356169	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IGI IGI: Inferred from genetic interaction	7744009	MGI
involved in positive regulation of thyroid hormone receptor signaling pathway	IDA IDA: Inferred from direct assay	8910441	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15340084	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	1312497	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	7823919	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23775127	MGI
acts upstream of or within positive regulation of translational initiation by iron	IGI IGI: Inferred from genetic interaction	23775127	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15322135	MGI
acts upstream of or within regulation of branching involved in prostate gland morphogenesis	IMP IMP: Inferred from mutant phenotype	12183441	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	7760852	MGI
acts upstream of or within retinoic acid receptor signaling pathway	IDA IDA: Inferred from direct assay	1312497	MGI
involved in retinoic acid receptor signaling pathway	IDA IDA: Inferred from direct assay	1312497	MGI
acts upstream of or within retinoic acid receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	23775127	MGI
acts upstream of or within secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	IMP IMP: Inferred from mutant phenotype	12183441	MGI
acts upstream of or within ventricular cardiac muscle cell differentiation	IGI IGI: Inferred from genetic interaction	9428411	MGI
acts upstream of or within ventricular cardiac muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	9428411	MGI
acts upstream of or within ventricular cardiac muscle tissue morphogenesis	IMP IMP: Inferred from mutant phenotype	9428411	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA polymerase II transcription regulator complex	EXP EXP: Inferred from Experiment	19167885	MGI
part of RNA polymerase II transcription regulator complex	IDA IDA: Inferred from direct assay	8910441	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10385625	MGI
part of transcription regulator complex	EXP EXP: Inferred from Experiment	10882070	MGI
part of transcription regulator complex	IPI IPI: Inferred from physical interaction	21152046	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

retinoic acid receptor RXR-alpha

RXR alpha 1

nuclear receptor subfamily 2 group B member 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12361	RXRA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-121435	K-8012		98.24%	Unkown
HY-160212	JP3000	Agonist	/	Unkown
HY-RS17966	Rxra Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24437	Rxra Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rxra	NCBI	NCBI:6256

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