Rrm1 - ribonucleotide reductase M1 Gene

Mus musculus

Also known as RnrM1

Gene ID: 20133 | Gene type: protein coding

About Rrm1

Summary

Enables disordered domain specific binding activity and purine nucleotide binding activity. Contributes to ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Involved in deoxyribonucleotide biosynthetic process and protein heterotetramerization. Part of ribonucleoside-diphosphate reductase complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human RRM1 (ribonucleotide reductase catalytic subunit M1). [provided by Alliance of Genome Resources, Apr 2022]

Rrm1 Products(1)

mRNA	Protein	Name
NM_009103.3	NP_033129.2	ribonucleoside-diphosphate reductase large subunit

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables disordered domain specific binding	IPI IPI: Inferred from physical interaction	8130196	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16829694	MGI
enables purine nucleotide binding	IDA IDA: Inferred from direct assay	16861739	MGI
contributes to ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	IDA IDA: Inferred from direct assay	16861739	MGI
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	IDA IDA: Inferred from direct assay	19176520	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in 2'-deoxyribonucleotide biosynthetic process	IDA IDA: Inferred from direct assay	12578384	MGI
involved in deoxyribonucleotide biosynthetic process	IDA IDA: Inferred from direct assay	19176520	MGI
involved in mitochondrial DNA replication	IMP IMP: Inferred from mutant phenotype	17486094	MGI
involved in positive regulation of G0 to G1 transition	IDA IDA: Inferred from direct assay	11517226	MGI
involved in protein heterotetramerization	IPI IPI: Inferred from physical interaction	19176520	MGI
involved in ribonucleoside diphosphate metabolic process	IDA IDA: Inferred from direct assay	12578384	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of ribonucleoside-diphosphate reductase complex	IDA IDA: Inferred from direct assay	19176520	MGI
part of ribonucleoside-diphosphate reductase complex	IMP IMP: Inferred from mutant phenotype	8130196	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ribonucleoside-diphosphate reductase large subunit

ribonucleoside-diphosphate reductase subunit M1

ribonucleotide reductase large subunit

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153898	rTRD01	Ligand	99.10%	Unkown
HY-153736	NSC 194308		98.40%	Unkown
HY-RS12285	RRM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18637	Rrm1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25122	Rrm1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rrm1	NCBI	NCBI:6240

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