2. Gene
  3. Rpe65 - retinal pigment epithelium 65 Gene

Rpe65 - retinal pigment epithelium 65 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as LCA2; RP20; rd12; 65kDa; Mord1; A930029L06Rik

Gene ID: 19892 | Gene type: protein coding

About Rpe65

Summary

Enables retinal isomerase activity. Acts upstream of or within several processes, including cellular response to electrical stimulus; Insulin Receptor signaling pathway; and retinal metabolic process. Located in cytoplasm; nucleus; and plasma membrane. Is expressed in eye; pelvic urothelial lining; pigmented retinal epithelium; and urothelium of ureter. Used to study Leber congenital amaurosis 2 and retinitis pigmentosa 20. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 2; retinitis pigmentosa; retinitis pigmentosa 20; and retinitis pigmentosa 87. Orthologous to human RPE65 (retinoid isomerohydrolase RPE65). [provided by Alliance of Genome Resources, Apr 2022]

Rpe65 Products(1)

mRNA Protein Name
NM_029987.2 NP_084263.2 retinoid isomerohydrolase
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
21493626 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
26404741 MGI
located in nucleus IDA
IDA: Inferred from direct assay
26404741 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
26404741 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

retinoid isomerohydrolase

all-trans-retinyl-palmitate hydrolase

lutein isomerase

meso-zeaxanthin isomerase

modifier of retinal degeneration 1

retinal pigment epithelium, 65 kDa

retinal pigment epithelium-specific 65 kDa protein

retinol isomerase

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-19720A Emixustat hydrochloride 99.29% Phase 3
HY-19720 Emixustat 98.00% Phase 3
Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-149325 RPE65-IN-1 ≥98.0% Unkown
HY-RS12151 RPE65 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS22780 Rpe65 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rpe65 NCBI NCBI:6121