Robo1 - roundabout guidance receptor 1 Gene

Mus musculus

Also known as DUTT1; Gm310

Gene ID: 19876 | Gene type: protein coding

About Robo1

Summary

Predicted to enable LRR domain binding activity; axon guidance receptor activity; and identical protein binding activity. Involved in several processes, including circulatory system development; neuron development; and regulation of gene expression. Acts upstream of or within animal organ development; axon guidance; and negative regulation of cell population proliferation. Located in axolemma. Is expressed in several structures, including central nervous system; foot; genitourinary system; jaw; and sensory organ. Used to study cystic kidney disease and lung Cancer. Orthologous to human ROBO1 (roundabout guidance receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Robo1 Products(1)

mRNA	Protein	Name
NM_019413.2	NP_062286.2	roundabout homolog 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19684588	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in aorta development	IGI IGI: Inferred from genetic interaction	25691540	MGI
involved in aortic valve morphogenesis	IGI IGI: Inferred from genetic interaction	25691540	MGI
acts upstream of or within axon guidance	IMP IMP: Inferred from mutant phenotype	15084255	MGI
involved in axon midline choice point recognition	IGI IGI: Inferred from genetic interaction	18986510	MGI
acts upstream of or within coronary vasculature development	IMP IMP: Inferred from mutant phenotype	25807483	MGI
involved in endocardial cushion formation	IGI IGI: Inferred from genetic interaction	25691540	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	25807483	MGI
involved in heart induction	IDA IDA: Inferred from direct assay	25691540	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	27002738	MGI
acts upstream of or within mammary duct terminal end bud growth	IMP IMP: Inferred from mutant phenotype	16439476	MGI
acts upstream of or within negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	18829537	MGI
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	25691540	MGI
involved in olfactory bulb interneuron development	IGI IGI: Inferred from genetic interaction	17360927	MGI
involved in outflow tract septum morphogenesis	IGI IGI: Inferred from genetic interaction	25691540	MGI
involved in positive regulation of Notch signaling pathway	IDA IDA: Inferred from direct assay	25691540	MGI
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	25691540	MGI
involved in pulmonary valve morphogenesis	IGI IGI: Inferred from genetic interaction	25691540	MGI
acts upstream of or within ventricular septum development	IMP IMP: Inferred from mutant phenotype	25807483	MGI
involved in ventricular septum morphogenesis	IGI IGI: Inferred from genetic interaction	25691540	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in axolemma	IDA IDA: Inferred from direct assay	15084255	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

roundabout homolog 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12110	ROBO1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20096	Robo1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26599	Robo1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Robo1	NCBI	NCBI:6091
Rattus norvegicus	Robo1	NCBI	NCBI:58946

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