Rgs2 - regulator of G-protein signaling 2 Gene

Mus musculus

Also known as GOS8

Gene ID: 19735 | Gene type: protein coding

About Rgs2

Summary

Enables Adenylate Cyclase Inhibitor activity. Involved in several processes, including negative regulation of signal transduction; regulation of muscle system process; and relaxation of cardiac muscle. Acts upstream of or within brown fat cell differentiation and spermatogenesis. Located in cytoplasmic side of plasma membrane and cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and immune system. Orthologous to human RGS2 (regulator of G protein signaling 2). [provided by Alliance of Genome Resources, Apr 2022]

Rgs2 Products(1)

mRNA	Protein	Name
NM_009061.4	NP_033087.2	regulator of G-protein signaling 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables adenylate cyclase inhibitor activity	IMP IMP: Inferred from mutant phenotype	21164481	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17464283	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within brown fat cell differentiation	IDA IDA: Inferred from direct assay	18492766	MGI
involved in negative regulation of G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	19127022	MGI
involved in negative regulation of MAP kinase activity	IMP IMP: Inferred from mutant phenotype	19127022	MGI
involved in negative regulation of cardiac muscle hypertrophy	IMP IMP: Inferred from mutant phenotype	19127022	MGI
involved in negative regulation of phospholipase activity	IMP IMP: Inferred from mutant phenotype	19127022	MGI
involved in positive regulation of cardiac muscle contraction	IMP IMP: Inferred from mutant phenotype	19127022	MGI
involved in regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21291891	MGI
involved in relaxation of cardiac muscle	IMP IMP: Inferred from mutant phenotype	19127022	MGI
involved in relaxation of vascular associated smooth muscle	IMP IMP: Inferred from mutant phenotype	14608379	MGI
involved in spermatogenesis	IEP IEP: Inferred from expression pattern	14581517	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	21291891	MGI
located in cytosol	IMP IMP: Inferred from mutant phenotype	19127022	MGI
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	19127022	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

regulator of G-protein signaling 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-169282	RGS2–Galpha-q interaction-IN-1	Inhibitor	/	Unkown
HY-RS11916	RGS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18970	Rgs2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25460	Rgs2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rgs2	NCBI	NCBI:5997

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