Rarg - retinoic acid receptor, gamma Gene

Mus musculus

Also known as RARD; Nr1b3; RAR-gamma; RARgamma2

Gene ID: 19411 | Gene type: protein coding

About Rarg

Summary

Enables several functions, including DNA-binding transcription factor activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and retinoid X receptor binding activity. Involved in growth plate cartilage chondrocyte growth and limb development. Acts upstream of or within several processes, including animal organ development; regulation of apoptotic process; and regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and limb. Orthologous to human RARG (retinoic acid receptor gamma). [provided by Alliance of Genome Resources, Apr 2022]

Rarg Products(3)

mRNA	Protein	Name
NM_001042727.3	NP_001036192.1	retinoic acid receptor gamma isoform 2
NM_001411714.1	NP_001398643.1	retinoic acid receptor gamma isoform 1
NM_011244.5	NP_035374.3	retinoic acid receptor gamma isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	18439490	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	18439490	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	15327771	MGI
enables nuclear retinoid X receptor binding	IMP IMP: Inferred from mutant phenotype	18439490	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15327771	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Harderian gland development	IMP IMP: Inferred from mutant phenotype	8388780	MGI
acts upstream of or within anterior/posterior pattern specification	IGI IGI: Inferred from genetic interaction	11784046	MGI
acts upstream of or within anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	8388780	MGI
acts upstream of apoptotic process	IGI IGI: Inferred from genetic interaction	16207763	MGI
acts upstream of or within bone development	IGI IGI: Inferred from genetic interaction	7607067	MGI
involved in bone development	IMP IMP: Inferred from mutant phenotype	19389355	MGI
acts upstream of or within bone morphogenesis	IGI IGI: Inferred from genetic interaction	11784046	MGI
acts upstream of or within bone morphogenesis	IMP IMP: Inferred from mutant phenotype	8388780	MGI
acts upstream of cell population proliferation	IGI IGI: Inferred from genetic interaction	10075839	MGI
acts upstream of or within cellular response to leukemia inhibitory factor	IEP IEP: Inferred from expression pattern	20439489	MGI
involved in chondrocyte development	IMP IMP: Inferred from mutant phenotype	19389355	MGI
acts upstream of or within embryonic camera-type eye development	IGI IGI: Inferred from genetic interaction	7607067	MGI
acts upstream of or within embryonic eye morphogenesis	IGI IGI: Inferred from genetic interaction	16207763	MGI
acts upstream of or within embryonic hindlimb morphogenesis	IGI IGI: Inferred from genetic interaction	10075839	MGI
acts upstream of or within epithelium development	IMP IMP: Inferred from mutant phenotype	8388780	MGI
acts upstream of or within face development	IGI IGI: Inferred from genetic interaction	7607067	MGI
acts upstream of or within gland development	IMP IMP: Inferred from mutant phenotype	8388780	MGI
acts upstream of or within glandular epithelial cell development	IGI IGI: Inferred from genetic interaction	7607067	MGI
involved in growth plate cartilage chondrocyte growth	IMP IMP: Inferred from mutant phenotype	19389355	MGI
acts upstream of or within growth plate cartilage development	IGI IGI: Inferred from genetic interaction	19389355	MGI
acts upstream of or within limb development	IGI IGI: Inferred from genetic interaction	7607067	MGI
involved in limb development	IMP IMP: Inferred from mutant phenotype	19389355	MGI
acts upstream of or within multicellular organism growth	IGI IGI: Inferred from genetic interaction	19389355	MGI
acts upstream of or within negative regulation of cartilage development	IMP IMP: Inferred from mutant phenotype	10684250	MGI
acts upstream of or within negative regulation of cell differentiation	IMP IMP: Inferred from mutant phenotype	10684250	MGI
acts upstream of or within negative regulation of chondrocyte differentiation	IMP IMP: Inferred from mutant phenotype	10684250	MGI
acts upstream of or within negative regulation of stem cell proliferation	IGI IGI: Inferred from genetic interaction	10075839	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8152920	MGI
acts upstream of or within neural tube closure	IGI IGI: Inferred from genetic interaction	7607067	MGI
acts upstream of or within positive regulation of apoptotic process	IGI IGI: Inferred from genetic interaction	16207763	MGI
acts upstream of or within positive regulation of gene expression	IDA IDA: Inferred from direct assay	19389355	MGI
acts upstream of or within positive regulation of programmed cell death	IGI IGI: Inferred from genetic interaction	10075839	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15327771	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15766748	MGI
acts upstream of programmed cell death	IGI IGI: Inferred from genetic interaction	10075839	MGI
acts upstream of or within prostate gland epithelium morphogenesis	IMP IMP: Inferred from mutant phenotype	8388780	MGI
acts upstream of or within regulation of gene expression	IGI IGI: Inferred from genetic interaction	19389355	MGI
acts upstream of or within regulation of myeloid cell differentiation	IGI IGI: Inferred from genetic interaction	23136256	MGI
acts upstream of or within reproductive structure development	IMP IMP: Inferred from mutant phenotype	8388780	MGI
acts upstream of or within retinoic acid receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	8388780	MGI
acts upstream of stem cell proliferation	IGI IGI: Inferred from genetic interaction	10075839	MGI
acts upstream of or within trachea cartilage development	IMP IMP: Inferred from mutant phenotype	8388780	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	15327771	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	18439490	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

retinoic acid receptor gamma

RAR gamma 2	nuclear receptor subfamily 1 group B member 3
retinoic acid receptor gamma 4

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-155108B	OATD-02 hydrochloride	Inhibitor	99.88%	Unkown
HY-155108	OATD-02	Inhibitor	/	Unkown
HY-RS11673	RARG Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22294	Rarg Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rarg	NCBI	NCBI:5916

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