Rab34 - RAB34, member RAS oncogene family Gene

Mus musculus

Also known as Rah; Narr; Rah1

Gene ID: 19376 | Gene type: protein coding

About Rab34

Summary

Enables GTPase activity and guanyl nucleotide binding activity. Involved in several processes, including Golgi to plasma membrane protein transport; phagosome-lysosome fusion; and positive regulation of protein localization to phagocytic vesicle. Acts upstream of or within endocytosis. Located in Golgi apparatus; endosome; and ruffle. Colocalizes with phagocytic vesicle. Is expressed in several structures, including adrenal gland; alimentary system; brain; genitourinary system; and respiratory system. Orthologous to human RAB34 (RAB34, member Ras oncogene family). [provided by Alliance of Genome Resources, Apr 2022]

Rab34 Products(2)

mRNA	Protein	Name
NM_001159482.1	NP_001152954.1	ras-related protein Rab-34
NM_033475.3	NP_258436.2	ras-related protein Rab-34

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase activity	IDA IDA: Inferred from direct assay	12446704	MGI
enables guanyl nucleotide binding	IDA IDA: Inferred from direct assay	12446704	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	22275436	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in Golgi to plasma membrane protein transport	IGI IGI: Inferred from genetic interaction	17881736	MGI
involved in cytosolic ciliogenesis	IMP IMP: Inferred from mutant phenotype	33989524	MGI
acts upstream of or within endocytosis	IDA IDA: Inferred from direct assay	12446704	MGI
involved in lysosomal transport	IDA IDA: Inferred from direct assay	23197834	MGI
involved in phagosome-lysosome fusion	IMP IMP: Inferred from mutant phenotype	23197834	MGI
involved in positive regulation of defense response to bacterium	IDA IDA: Inferred from direct assay	23197834	MGI
involved in positive regulation of protein localization to phagocytic vesicle	IMP IMP: Inferred from mutant phenotype	23197834	MGI
involved in positive regulation of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	29290584	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	23197834	MGI
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	23197834	MGI
located in early endosome	IDA IDA: Inferred from direct assay	12446704	MGI
located in late endosome	IDA IDA: Inferred from direct assay	23197834	MGI
colocalizes with phagocytic vesicle	IDA IDA: Inferred from direct assay	23197834	MGI
located in ruffle	IDA IDA: Inferred from direct assay	12446704	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ras-related protein Rab-34

RAB34, member of RAS oncogene family	rab-39
ras-related homolog	ras-related protein Rab-39
ras-related protein Rah

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11548	RAB34 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22761	Rab34 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29275	Rab34 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rab34	NCBI	NCBI:83871

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