Purb - purine rich element binding protein B Gene

Mus musculus

Also known as Cager-2; D11Bwg0414e; 2310015K15Rik

Gene ID: 19291 | Gene type: protein coding

About Purb

Summary

Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; SMAD binding activity; and nucleic acid binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within negative regulation of transcription, DNA-templated. Located in nucleus. Is expressed in heart and hindlimb muscle. Orthologous to human PURB (purine rich element binding protein B). [provided by Alliance of Genome Resources, Apr 2022]

Purb Products(1)

mRNA	Protein	Name
NM_011221.3	NP_035351.1	transcriptional activator protein Pur-beta

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	15282343	MGI
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	10318844	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15282343	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	27064749	MGI
enables RNA binding	IDA IDA: Inferred from direct assay	23723417	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15282343	MGI
enables SMAD binding	IDA IDA: Inferred from direct assay	15282343	MGI
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	15282343	MGI
enables mRNA binding	IDA IDA: Inferred from direct assay	12933792	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15282343	MGI
enables single-stranded DNA binding	IDA IDA: Inferred from direct assay	10318844	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15282343	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15282343	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	23723417	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	31918924	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	15282343	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transcriptional activator protein Pur-beta

PurB beta	purine-rich single-stranded DNA-binding protein beta
vascular actin single-stranded DNA-binding factor 2 p44 component

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11465	PURB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21412	Purb Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Purb	NCBI	NCBI:5814

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