2. Gene
  3. Itgb4 - integrin beta 4 Gene

Itgb4 - integrin beta 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as CD104; C230078O20

Gene ID: 192897 | Gene type: protein coding

About Itgb4

Summary

Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated Transmembrane Glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the Integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Itgb4 Products(4)

mRNA Protein Name
NM_001005608.3 NP_001005608.2 integrin beta-4 isoform 1 precursor
NM_001405126.1 NP_001392055.1 integrin beta-4 isoform 4 precursor
NM_001405127.1 NP_001392056.1 integrin beta-4 isoform 3 precursor
NM_133663.3 NP_598424.2 integrin beta-4 isoform 2 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16436605 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cell adhesion IMP
IMP: Inferred from mutant phenotype
8707838 MGI
acts upstream of or within filopodium assembly IMP
IMP: Inferred from mutant phenotype
16365040 MGI
acts upstream of or within myelination in peripheral nervous system IGI
IGI: Inferred from genetic interaction
29315582 MGI
acts upstream of or within peripheral nervous system myelin formation IGI
IGI: Inferred from genetic interaction
29315582 MGI
acts upstream of or within trophoblast cell migration IMP
IMP: Inferred from mutant phenotype
21606200 MGI
Cellular Component GO Annotation Evidence Reference Source
located in basal plasma membrane IDA
IDA: Inferred from direct assay
11891657 MGI
located in basement membrane IDA
IDA: Inferred from direct assay
17011173 MGI
located in cell surface IDA
IDA: Inferred from direct assay
16436605 MGI
located in hemidesmosome IDA
IDA: Inferred from direct assay
21606200 MGI
part of integrin complex IDA
IDA: Inferred from direct assay
8707838 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

integrin beta-4

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-125355 SEC 98.26% Phase 1
Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06968 ITGB4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17507 Itgb4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23964 Itgb4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Itgb4 NCBI NCBI:3691