2. Gene
  3. Pts - 6-pyruvoyl-tetrahydropterin synthase Gene

Pts - 6-pyruvoyl-tetrahydropterin synthase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as PTPS

Gene ID: 19286 | Gene type: protein coding

About Pts

Summary

Enables 6-pyruvoyltetrahydropterin synthase activity and identical protein binding activity. Acts upstream of or within tetrahydrobiopterin biosynthetic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study BH4-deficient hyperphenylalaninemia A. Human ortholog(s) of this gene implicated in BH4-deficient hyperphenylalaninemia A and phenylketonuria. Orthologous to human PTS (6-pyruvoyltetrahydropterin synthase). [provided by Alliance of Genome Resources, Apr 2022]

Pts Products(34)

mRNA Protein Name
NM_001364488.1 NP_001351417.1 6-pyruvoyl tetrahydrobiopterin synthase isoform 2
NM_001364489.1 NP_001351418.1 6-pyruvoyl tetrahydrobiopterin synthase isoform 2
NM_001364490.1 NP_001351419.1 6-pyruvoyl tetrahydrobiopterin synthase isoform 2
NM_001409182.1 NP_001396111.1 6-pyruvoyl tetrahydrobiopterin synthase isoform 2
NM_001409183.1 NP_001396112.1 6-pyruvoyl tetrahydrobiopterin synthase isoform 2
NM_001409184.1 NP_001396113.1 6-pyruvoyl tetrahydrobiopterin synthase isoform 2
NM_001409185.1 NP_001396114.1 6-pyruvoyl tetrahydrobiopterin synthase isoform 2
NM_001409186.1 NP_001396115.1 6-pyruvoyl tetrahydrobiopterin synthase isoform 2
NM_001409187.1 NP_001396116.1 6-pyruvoyl tetrahydrobiopterin synthase isoform 2
NM_001409188.1 NP_001396117.1 6-pyruvoyl tetrahydrobiopterin synthase isoform 2
NM_001409189.1 NP_001396118.1 6-pyruvoyl tetrahydrobiopterin synthase isoform 2
NM_001409190.1 NP_001396119.1 6-pyruvoyl tetrahydrobiopterin synthase isoform 2
NM_001409191.1 NP_001396120.1 6-pyruvoyl tetrahydrobiopterin synthase isoform 2
NM_001409192.1 NP_001396121.1 6-pyruvoyl tetrahydrobiopterin synthase isoform 2
NM_001409193.1 NP_001396122.1 6-pyruvoyl tetrahydrobiopterin synthase isoform 2
NM_001409194.1 NP_001396123.1 6-pyruvoyl tetrahydrobiopterin synthase isoform 2
NM_001409195.1 NP_001396124.1 6-pyruvoyl tetrahydrobiopterin synthase isoform 2
NM_001409196.1 NP_001396125.1 6-pyruvoyl tetrahydrobiopterin synthase isoform 2
NM_001409197.1 NP_001396126.1 6-pyruvoyl tetrahydrobiopterin synthase isoform 2
NM_001409198.1 NP_001396127.1 6-pyruvoyl tetrahydrobiopterin synthase isoform 2
NM_001409199.1 NP_001396128.1 6-pyruvoyl tetrahydrobiopterin synthase isoform 2
NM_001409200.1 NP_001396129.1 6-pyruvoyl tetrahydrobiopterin synthase isoform 2
NM_001409201.1 NP_001396130.1 6-pyruvoyl tetrahydrobiopterin synthase isoform 2
NM_001409202.1 NP_001396131.1 6-pyruvoyl tetrahydrobiopterin synthase isoform 2
NM_001409203.1 NP_001396132.1 6-pyruvoyl tetrahydrobiopterin synthase isoform 3
NM_001409204.1 NP_001396133.1 6-pyruvoyl tetrahydrobiopterin synthase isoform 3
NM_001409205.1 NP_001396134.1 6-pyruvoyl tetrahydrobiopterin synthase isoform 3
NM_001409206.1 NP_001396135.1 6-pyruvoyl tetrahydrobiopterin synthase isoform 3
NM_001409207.1 NP_001396136.1 6-pyruvoyl tetrahydrobiopterin synthase isoform 3
NM_001409209.1 NP_001396138.1 6-pyruvoyl tetrahydrobiopterin synthase isoform 4
NM_001409210.1 NP_001396139.1 6-pyruvoyl tetrahydrobiopterin synthase isoform 5
NM_001409211.1 NP_001396140.1 6-pyruvoyl tetrahydrobiopterin synthase isoform 6
NM_001409214.1 NP_001396143.1 6-pyruvoyl tetrahydrobiopterin synthase isoform 8
NM_011220.3 NP_035350.1 6-pyruvoyl tetrahydrobiopterin synthase isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables 6-pyruvoyltetrahydropterin synthase activity IDA
IDA: Inferred from direct assay
9894812 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
9894812 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within tetrahydrobiopterin biosynthetic process IDA
IDA: Inferred from direct assay
9894812 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

6-pyruvoyl tetrahydrobiopterin synthase

PTP synthase

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-106031 F-14512 97.48% Phase 2
Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-147062 N-Acetyl-D-galactosamine-6-phosphate 99.6% Unkown
HY-W601362 N-Acetyl-D-galactosamine-6-phosphate disodium 98.61% Unkown
HY-143456 Anti-inflammatory agent 18 Inhibitor / Unkown
HY-143457 Anti-inflammatory agent 19 Inhibitor / Unkown
HY-P10230 Sublancin Inhibitor / Unkown
HY-RS11455 PTS Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-116259 PT-S58 Antagonist / Unkown
HY-RS20244 Pts Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS26752 Pts Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pts NCBI NCBI:5805