Ptprs - protein tyrosine phosphatase, receptor type, S Gene

Mus musculus

Also known as PTP; Ptpt9; PTP-NU3; PTPNU-3; R-PTP-S; PTPsigma; RPTPsigma

Gene ID: 19280 | Gene type: protein coding

About Ptprs

Summary

Enables chondroitin sulfate binding activity; heparin binding activity; and protein tyrosine Phosphatase activity. Involved in several processes, including negative regulation of neuron projection development; peptidyl-tyrosine dephosphorylation; and regulation of postsynaptic density assembly. Acts upstream of or within central nervous system development and establishment of endothelial intestinal barrier. Located in Schaffer collateral - CA1 synapse; glutamatergic synapse; and plasma membrane. Is integral component of presynaptic membrane. Is expressed in several structures, including adipose tissue; genitourinary system; gut; nervous system; and sensory organ. Orthologous to human PTPRS (protein tyrosine Phosphatase receptor type S). [provided by Alliance of Genome Resources, Apr 2022]

Ptprs Products(4)

mRNA	Protein	Name
NM_001252453.1	NP_001239382.1	receptor-type tyrosine-protein phosphatase S isoform 2 precursor
NM_001252455.1	NP_001239384.1	receptor-type tyrosine-protein phosphatase S isoform 3 precursor
NM_001252456.1	NP_001239385.1	receptor-type tyrosine-protein phosphatase S isoform 2 precursor
NM_011218.2	NP_035348.2	receptor-type tyrosine-protein phosphatase S isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chondroitin sulfate binding	IDA IDA: Inferred from direct assay	22406547	MGI
enables heparin binding	IDA IDA: Inferred from direct assay	22406547	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	24385580	MGI
enables protein tyrosine phosphatase activity	IDA IDA: Inferred from direct assay	7529177	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cerebellum development	IMP IMP: Inferred from mutant phenotype	15842738	MGI
acts upstream of or within cerebral cortex development	IMP IMP: Inferred from mutant phenotype	15842738	MGI
acts upstream of or within corpus callosum development	IMP IMP: Inferred from mutant phenotype	15842738	MGI
acts upstream of or within establishment of endothelial intestinal barrier	IMP IMP: Inferred from mutant phenotype	24385580	MGI
acts upstream of or within hippocampus development	IMP IMP: Inferred from mutant phenotype	15842738	MGI
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	22519304	MGI
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	22519304	MGI
involved in negative regulation of axon extension	IMP IMP: Inferred from mutant phenotype	19780196	MGI
involved in negative regulation of axon regeneration	IMP IMP: Inferred from mutant phenotype	19780196	MGI
involved in negative regulation of collateral sprouting	IMP IMP: Inferred from mutant phenotype	22519304	MGI
involved in negative regulation of dendritic spine development	IMP IMP: Inferred from mutant phenotype	22519304	MGI
involved in negative regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	22406547	MGI
involved in peptidyl-tyrosine dephosphorylation	IDA IDA: Inferred from direct assay	7529177	MGI
acts upstream of or within peptidyl-tyrosine dephosphorylation	IMP IMP: Inferred from mutant phenotype	24385580	MGI
involved in regulation of postsynaptic density assembly	IDA IDA: Inferred from direct assay	21262467	MGI
involved in regulation of postsynaptic density assembly	IMP IMP: Inferred from mutant phenotype	21262467	MGI
acts upstream of or within spinal cord development	IMP IMP: Inferred from mutant phenotype	15842738	MGI
involved in synapse organization	IDA IDA: Inferred from direct assay	22519304	MGI
involved in synapse organization	IMP IMP: Inferred from mutant phenotype	22519304	MGI
involved in trans-synaptic signaling	IDA IDA: Inferred from direct assay	32142410	MGI
involved in trans-synaptic signaling	IMP IMP: Inferred from mutant phenotype	32142410	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	22519304	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	22519304	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	21262467	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	21262467	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	26231120	MGI
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	21262467	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

receptor-type tyrosine-protein phosphatase S

R-PTP-sigma	Receptor-type tyrosine-protein phosphatase sigma
tissue-specific protein tyrosine phosphatase

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11449	PTPRS Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21709	Ptprs Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28227	Ptprs Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ptprs	NCBI	NCBI:5802

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