2. Gene
  3. Ptprn - protein tyrosine phosphatase, receptor type, N Gene

Ptprn - protein tyrosine phosphatase, receptor type, N Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as IA-2; mIA-A; R-PTP-N; PTP IA-2; mKIAA4064

Gene ID: 19275 | Gene type: protein coding

About Ptprn

Summary

Predicted to enable GTPase binding activity; spectrin binding activity; and ubiquitin-like protein Ligase binding activity. Involved in Insulin secretion involved in cellular response to glucose stimulus; luteinization; and positive regulation of type B pancreatic cell proliferation. Predicted to be located in several cellular components, including axon terminus; neuronal cell body; and secretory granule. Predicted to colocalize with Golgi apparatus; endosome; and plasma membrane. Is expressed in lens vesicle and nervous system. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human PTPRN (protein tyrosine Phosphatase receptor type N). [provided by Alliance of Genome Resources, Apr 2022]

Ptprn Products(4)

mRNA Protein Name
NM_001359281.2 NP_001346210.1 receptor-type tyrosine-protein phosphatase-like N isoform 2
NM_001405067.1 NP_001391996.1 receptor-type tyrosine-protein phosphatase-like N isoform 3
NM_001405068.2 NP_001391997.1 receptor-type tyrosine-protein phosphatase-like N isoform 2
NM_008985.4 NP_033011.2 receptor-type tyrosine-protein phosphatase-like N isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12364328 MGI
NOT enables protein tyrosine phosphatase activity IDA
IDA: Inferred from direct assay
8878556 MGI
Biological Process GO Annotation Evidence Reference Source
involved in insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
12031972 MGI
involved in luteinization IMP
IMP: Inferred from mutant phenotype
16269463 MGI
involved in positive regulation of type B pancreatic cell proliferation IMP
IMP: Inferred from mutant phenotype
18178618 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

receptor-type tyrosine-protein phosphatase-like N

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11444 PTPRN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11445 PTPRN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20475 Ptprn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26983 Ptprn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptprn NCBI NCBI:5798