Ptprj - protein tyrosine phosphatase, receptor type, J Gene

Mus musculus

Also known as BET; Byp; Scc1; CD148; DEP-1; Ptpb2; RPTPJ; Scc-1; R-PTP-J; PTPbeta2; R-PTP-eta

Gene ID: 19271 | Gene type: protein coding

About Ptprj

Summary

Enables protein tyrosine Phosphatase activity. Involved in several processes, including regulation of cell migration; regulation of protein phosphorylation; and regulation of signal transduction. Acts upstream of or within heart development; oligodendrocyte differentiation; and vasculogenesis. Located in immunological synapse and ruffle membrane. Is expressed in midbrain; renal calyx; renal pelvis; and superior colliculus. Human ortholog(s) of this gene implicated in colorectal Cancer. Orthologous to human PTPRJ (protein tyrosine Phosphatase receptor type J). [provided by Alliance of Genome Resources, Apr 2022]

Ptprj Products(2)

mRNA	Protein	Name
NM_001135657.1	NP_001129129.1	receptor-type tyrosine-protein phosphatase eta isoform 2
NM_008982.6	NP_033008.4	receptor-type tyrosine-protein phosphatase eta isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein tyrosine phosphatase activity	IMP IMP: Inferred from mutant phenotype	12771128	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in B cell differentiation	IMP IMP: Inferred from mutant phenotype	18249142	MGI
involved in blood coagulation	IMP IMP: Inferred from mutant phenotype	19246339	MGI
involved in glucose homeostasis	IMP IMP: Inferred from mutant phenotype	26063811	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	12588999	MGI
involved in negative regulation of MAP kinase activity	IDA IDA: Inferred from direct assay	12833140	MGI
involved in negative regulation of T cell receptor signaling pathway	IDA IDA: Inferred from direct assay	12913111	MGI
involved in negative regulation of cell migration	IDA IDA: Inferred from direct assay	12833140	MGI
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	12771128	MGI
involved in negative regulation of insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	26063811	MGI
involved in negative regulation of platelet-derived growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	12833140	MGI
involved in negative regulation of signaling receptor activity	IMP IMP: Inferred from mutant phenotype	12771128	MGI
acts upstream of or within oligodendrocyte differentiation	IMP IMP: Inferred from mutant phenotype	19139271	MGI
involved in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	26063811	MGI
involved in positive regulation of Fc receptor mediated stimulatory signaling pathway	IGI IGI: Inferred from genetic interaction	18249142	MGI
involved in positive regulation of MAPK cascade	IGI IGI: Inferred from genetic interaction	18249142	MGI
involved in positive regulation of calcium-mediated signaling	IGI IGI: Inferred from genetic interaction	18249142	MGI
involved in positive regulation of cell-matrix adhesion	IDA IDA: Inferred from direct assay	12833140	MGI
involved in positive regulation of macrophage chemotaxis	IDA IDA: Inferred from direct assay	19268662	MGI
involved in positive regulation of peptidyl-tyrosine phosphorylation	IGI IGI: Inferred from genetic interaction	18249142	MGI
involved in positive regulation of phagocytosis	IGI IGI: Inferred from genetic interaction	18249142	MGI
involved in positive regulation of platelet activation	IMP IMP: Inferred from mutant phenotype	19246339	MGI
involved in positive regulation of tumor necrosis factor production	IGI IGI: Inferred from genetic interaction	18249142	MGI
acts upstream of or within vasculogenesis	IMP IMP: Inferred from mutant phenotype	12588999	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in immunological synapse	IDA IDA: Inferred from direct assay	12913111	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	19268662	MGI
located in ruffle membrane	IDA IDA: Inferred from direct assay	19268662	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

receptor-type tyrosine-protein phosphatase eta

HPTP beta-like tyrosine phosphatase	colon tumor susceptibility 1
protein-tyrosine phosphatase eta	susceptibility to colon cancer 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11441	PTPRJ Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18679	Ptprj Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25165	Ptprj Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ptprj	NCBI	NCBI:5795

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