Mfn1 - mitofusin 1 Gene

Rattus norvegicus

Also known as Fzo1b

Gene ID: 192647 | Gene type: protein coding

About Mfn1

Summary

Enables identical protein binding activity. Involved in several processes, including cellular response to decreased oxygen levels; regulation of mitochondrion organization; and response to glucocorticoid. Located in mitochondrial inner membrane and mitochondrial outer membrane. Biomarker of several diseases, including adult respiratory distress syndrome; dental fluorosis; kidney failure (multiple); pulmonary hypertension; and status epilepticus. Orthologous to human MFN1 (mitofusin 1). [provided by Alliance of Genome Resources, Apr 2022]

Mfn1 Products(1)

mRNA	Protein	Name
NM_138976.2	NP_620432.2	mitofusin-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	14561718	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to dexamethasone stimulus	IEP IEP: Inferred from expression pattern	22703557	RGD
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	28518143	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	23658809	RGD
involved in intracellular distribution of mitochondria	IMP IMP: Inferred from mutant phenotype	19605646	RGD
involved in male gonad development	IEP IEP: Inferred from expression pattern	14592431	RGD
involved in mitochondrion organization	IMP IMP: Inferred from mutant phenotype	19605646	RGD
involved in negative regulation of mitochondrial fission	IMP IMP: Inferred from mutant phenotype	18832378	RGD
involved in positive regulation of dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	19605646	RGD
involved in positive regulation of mitochondrial fusion	IMP IMP: Inferred from mutant phenotype	24751540	RGD
involved in response to calcium ion	IEP IEP: Inferred from expression pattern	25308841	RGD
involved in response to corticosterone	IEP IEP: Inferred from expression pattern	22244747	RGD
involved in response to electrical stimulus	IEP IEP: Inferred from expression pattern	26513006	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	24751540	RGD
involved in response to flavonoid	IEP IEP: Inferred from expression pattern	24637344	RGD
involved in response to fluoride	IEP IEP: Inferred from expression pattern	24958380	RGD
involved in response to hypobaric hypoxia	IEP IEP: Inferred from expression pattern	24637344	RGD
involved in response to manganese ion	IEP IEP: Inferred from expression pattern	15589972	RGD
involved in response to muscle activity	IEP IEP: Inferred from expression pattern	19716857	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	25336449	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	27801955	RGD
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	27801955	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

mitofusin-1

mitochondrial transmembrane GTPase FZO1B

transmembrane GTPase MFN1

Mfn1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80751	Mitofusin 1 Antibody	WB, IP	Mouse, Rat, Hamster

Related Agents

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-150031	MFI8	Inhibitor	99.44%	Unkown
HY-126124	AP39		96.35%	Unkown
HY-P3429A	SAMβA TFA	Inhibitor	99.13%	Unkown
HY-P3429	SAMβA	Inhibitor	/	Unkown
HY-P5891	TAT-SAMβA	Antagonist	/	Unkown
HY-RS08383	MFN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17749	Mfn1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24215	Mfn1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mfn1	NCBI	NCBI:55669

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