Dusp1 - dual specificity phosphatase 1 Gene

Mus musculus

Also known as erp; MKP1; mkp-1; 3CH134; Ptpn16

Gene ID: 19252 | Gene type: protein coding

About Dusp1

Summary

Enables mitogen-activated protein kinase binding activity and phosphoprotein Phosphatase activity. Involved in negative regulation of MAPK cascade; negative regulation of cell population proliferation; and protein dephosphorylation. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in breast Cancer. Orthologous to human DUSP1 (dual specificity Phosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]

Dusp1 Products(1)

mRNA	Protein	Name
NM_013642.3	NP_038670.1	dual specificity protein phosphatase 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables MAP kinase tyrosine/serine/threonine phosphatase activity	IMP IMP: Inferred from mutant phenotype	8221888	MGI
enables mitogen-activated protein kinase binding	IDA IDA: Inferred from direct assay	8221888	MGI
enables mitogen-activated protein kinase binding	IPI IPI: Inferred from physical interaction	8221888	MGI
enables protein serine/threonine phosphatase activity	IMP IMP: Inferred from mutant phenotype	8355678	MGI
enables protein tyrosine phosphatase activity	IMP IMP: Inferred from mutant phenotype	8355678	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	8221888	MGI
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	8355678	MGI
involved in peptidyl-serine dephosphorylation	IMP IMP: Inferred from mutant phenotype	8355678	MGI
involved in peptidyl-threonine dephosphorylation	IMP IMP: Inferred from mutant phenotype	8221888	MGI
involved in peptidyl-tyrosine dephosphorylation	IMP IMP: Inferred from mutant phenotype	8221888	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

dual specificity protein phosphatase 1

MAP kinase phosphatase 1	mitogen-activated protein kinase phosphatase-1
protein tyrosine phosphatase, non-receptor type 16	protein-tyrosine phosphatase 3CH134
protein-tyrosine phosphatase ERP

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N2179	Hypaphorine	Inhibitor	99.97%	Unkown
HY-RS04050	DUSP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS16828	Dusp1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23270	Dusp1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dusp1	NCBI	NCBI:1843

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