Twf1 - twinfilin actin binding protein 1 Gene

Mus musculus

Also known as A6; Ptk9; twinfilin

Gene ID: 19230 | Gene type: protein coding

About Twf1

Summary

Enables actin monomer binding activity; phosphatidylinositol-4,5-bisphosphate binding activity; and protein tyrosine kinase activity. Involved in barbed-end actin filament capping; positive regulation of cardiac muscle hypertrophy; and sequestering of actin monomers. Located in several cellular components, including filopodium; myofibril; and perinuclear region of cytoplasm. Colocalizes with ruffle membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human TWF1 (twinfilin actin binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Twf1 Products(3)

mRNA	Protein	Name
NM_001402809.1	NP_001389738.1	twinfilin-1 isoform 2
NM_001402810.1	NP_001389739.1	twinfilin-1 isoform 3
NM_008971.5	NP_032997.3	twinfilin-1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables actin monomer binding	IDA IDA: Inferred from direct assay	12807912	MGI
enables phosphatidylinositol-4,5-bisphosphate binding	IDA IDA: Inferred from direct assay	12807912	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17360616	MGI
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	9249064	MGI
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	11604420	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in barbed-end actin filament capping	IDA IDA: Inferred from direct assay	18837697	MGI
involved in negative regulation of actin filament polymerization	IDA IDA: Inferred from direct assay	12807912	MGI
involved in positive regulation of cardiac muscle hypertrophy	IDA IDA: Inferred from direct assay	20571053	MGI
involved in sequestering of actin monomers	IDA IDA: Inferred from direct assay	18837697	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in actin cytoskeleton	IDA IDA: Inferred from direct assay	10669753	MGI
located in cell-cell junction	IDA IDA: Inferred from direct assay	12807912	MGI
located in filopodium	IDA IDA: Inferred from direct assay	12807912	MGI
located in myofibril	IDA IDA: Inferred from direct assay	18837697	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	12807912	MGI
colocalizes with ruffle membrane	IDA IDA: Inferred from direct assay	12807912	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

twinfilin-1

PTK9 protein tyrosine kinase 9	actin monomer-binding protein
protein A6	protein tyrosine kinase 9
twinfilin, actin-binding protein, homolog 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15279	TWF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18978	Twf1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25467	Twf1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Twf1	NCBI	NCBI:5756

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