Pthlh - parathyroid hormone-like peptide Gene

Mus musculus

Also known as PLP; Pthrp; PTH-like

Gene ID: 19227 | Gene type: protein coding

About Pthlh

Summary

This gene encodes a member of the parathyroid family of Hormones that possesses distinct paracrine and intracrine signaling roles such as regulation of circulating calcium, transplacental calcium transport, osteoclast inhibition, renal bicarbonate excretion and regulation of Apoptosis. The encoded protein undergoes proteolytic processing to generate multiple active peptides with distinct signaling functions. The homozygous deletion of this gene leads to death shortly after birth with a chondrodystrophic phenotype characterized by premature chondrocyte differentiation and accelerated bone formation. [provided by RefSeq, Jul 2015]

Pthlh Products(1)

mRNA	Protein	Name
NM_008970.4	NP_032996.2	parathyroid hormone-related protein preproprotein

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
NOT acts upstream of or within bone mineralization	IMP IMP: Inferred from mutant phenotype	11606467	MGI
acts upstream of bone mineralization	IMP IMP: Inferred from mutant phenotype	19968565	MGI
acts upstream of chondrocyte differentiation	IMP IMP: Inferred from mutant phenotype	8895385	MGI
acts upstream of or within endochondral ossification	IMP IMP: Inferred from mutant phenotype	8895385	MGI
acts upstream of or within endoderm development	IDA IDA: Inferred from direct assay	9921650	MGI
acts upstream of or within lung alveolus development	IMP IMP: Inferred from mutant phenotype	15162506	MGI
acts upstream of or within lung epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	15162506	MGI
acts upstream of or within mammary gland bud elongation	IMP IMP: Inferred from mutant phenotype	9477327	MGI
acts upstream of or within negative regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	17328886	MGI
acts upstream of or within negative regulation of chondrocyte differentiation	IDA IDA: Inferred from direct assay	17328886	MGI
acts upstream of or within negative regulation of chondrocyte differentiation	IGI IGI: Inferred from genetic interaction	17328886	MGI
acts upstream of or within negative regulation of chondrocyte differentiation	IMP IMP: Inferred from mutant phenotype	8895385	MGI
acts upstream of or within nipple sheath formation	IMP IMP: Inferred from mutant phenotype	9477327	MGI
acts upstream of or within osteoblast development	IMP IMP: Inferred from mutant phenotype	9832460	MGI
acts upstream of or within positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	17328886	MGI
acts upstream of or within protein processing	IDA IDA: Inferred from direct assay	17328886	MGI
acts upstream of or within skeletal system development	IMP IMP: Inferred from mutant phenotype	8314082	MGI
acts upstream of or within surfactant homeostasis	IMP IMP: Inferred from mutant phenotype	15162506	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in intracellular anatomical structure	IDA IDA: Inferred from direct assay	8895385	MGI
located in nucleus	IDA IDA: Inferred from direct assay	26859332	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

parathyroid hormone-related protein

PTH-related peptide	parathyroid hormone-like hormone
parathyroid hormone-like protein	parathyroid hormone-related peptide

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11398	PTHLH Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21704	Pthlh Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28222	Pthlh Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pthlh	NCBI	NCBI:5744

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