2. Gene
  3. Ash1l - ASH1 like histone lysine methyltransferase Gene

Ash1l - ASH1 like histone lysine methyltransferase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Ash1; Kmt2h; 8030453L17Rik; E430018P19Rik

Gene ID: 192195 | Gene type: protein coding

About Ash1l

Summary

Enables Histone Methyltransferase activity (H3-K4 specific) and Histone Methyltransferase activity (H3-K9 specific). Acts upstream of or within several processes, including negative regulation of intracellular signal transduction; reproductive structure development; and tarsal gland development. Predicted to be located in Golgi apparatus and nucleoplasm. Is expressed in early conceptus; inner cell mass; oocyte; and ureter. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 52. Orthologous to human ASH1L (ASH1 like histone lysine methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Ash1l Products(1)

mRNA Protein Name
NM_138679.5 NP_619620.3 histone-lysine N-methyltransferase ASH1L
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables histone H3K4 methyltransferase activity IDA
IDA: Inferred from direct assay
24012418 MGI
enables histone H3K4 methyltransferase activity IMP
IMP: Inferred from mutant phenotype
24012418 MGI
enables histone H3K9 methyltransferase activity IDA
IDA: Inferred from direct assay
22939622 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of MAPK cascade IMP
IMP: Inferred from mutant phenotype
24012418 MGI
acts upstream of or within decidualization IMP
IMP: Inferred from mutant phenotype
26333994 MGI
acts upstream of or within flagellated sperm motility IMP
IMP: Inferred from mutant phenotype
26333994 MGI
acts upstream of inflammatory response IGI
IGI: Inferred from genetic interaction
24012418 MGI
acts upstream of or within interleukin-6 production IGI
IGI: Inferred from genetic interaction
24012418 MGI
acts upstream of or within macrophage cytokine production IGI
IGI: Inferred from genetic interaction
24012418 MGI
acts upstream of or within negative regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
24012418 MGI
acts upstream of or within negative regulation of acute inflammatory response IMP
IMP: Inferred from mutant phenotype
24012418 MGI
acts upstream of or within negative regulation of inflammatory response IGI
IGI: Inferred from genetic interaction
24012418 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
24012418 MGI
acts upstream of or within post-embryonic development IMP
IMP: Inferred from mutant phenotype
26333994 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
26333994 MGI
acts upstream of or within sebaceous gland development IMP
IMP: Inferred from mutant phenotype
26333994 MGI
acts upstream of or within single fertilization IMP
IMP: Inferred from mutant phenotype
26333994 MGI
acts upstream of or within skeletal system development IMP
IMP: Inferred from mutant phenotype
26333994 MGI
acts upstream of or within tarsal gland development IMP
IMP: Inferred from mutant phenotype
26333994 MGI
acts upstream of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
24012418 MGI
acts upstream of or within uterine gland development IMP
IMP: Inferred from mutant phenotype
26333994 MGI
acts upstream of or within uterus morphogenesis IMP
IMP: Inferred from mutant phenotype
26333994 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

histone-lysine N-methyltransferase ASH1L

ASH1-like protein

absent small and homeotic disks protein 1 homolog

absent, small, or homeotic discs 1

ash1 (absent, small, or homeotic)-like

chromatin remodeling factor

probable histone-lysine N-methyltransferase ASH1L

Related Agents

Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-141429A AS-99 TFA 99.15% Unkown
HY-141430 AS-85 Inhibitor 98.96% Unkown
HY-170494 AS-254s Inhibitor / Unkown
HY-141429 AS-99 free base / Unkown
HY-141429C AS-99 / Unkown
HY-RS01087 ASH1L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17758 Ash1l Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24225 Ash1l Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ash1l NCBI NCBI:55870