2. Gene
  3. Flna - filamin, alpha Gene

Flna - filamin, alpha Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Fln1; Dilp2; ABP-280; GENA 379; filamin-1; F730004A14Rik

Gene ID: 192176 | Gene type: protein coding

About Flna

Summary

Enables Potassium Channel regulator activity and protein kinase C binding activity. Involved in several processes, including circulatory system development; regulation of ion transmembrane transport; and regulation of neuron projection development. Acts upstream of or within actin Cytoskeleton organization; early endosome to late endosome transport; and epithelial to mesenchymal transition. Located in several cellular components, including Z disc; axonal growth cone; and trans-Golgi network. Is expressed in several structures, including bone; brain; great vessel of heart; gut; and heart. Used to study periventricular nodular heterotopia. Human ortholog(s) of this gene implicated in X-linked recessive disease (multiple); bone development disease (multiple); heart valve disease (multiple); periventricular nodular heterotopia; and terminal osseous dysplasia. Orthologous to human FLNA (filamin A). [provided by Alliance of Genome Resources, Apr 2022]

Flna Products(3)

mRNA Protein Name
NM_001290421.1 NP_001277350.1 filamin-A isoform 2
NM_001404064.1 NP_001390993.1 filamin-A isoform 3
NM_010227.3 NP_034357.2 filamin-A isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables potassium channel regulator activity IMP
IMP: Inferred from mutant phenotype
24951510 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
8871564 MGI
enables protein kinase C binding IDA
IDA: Inferred from direct assay
12704190 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within actin cytoskeleton organization IGI
IGI: Inferred from genetic interaction
21709252 MGI
involved in angiogenesis IMP
IMP: Inferred from mutant phenotype
17172441 MGI
involved in blood vessel remodeling IMP
IMP: Inferred from mutant phenotype
17172441 MGI
involved in cell-cell junction organization IMP
IMP: Inferred from mutant phenotype
17172441 MGI
acts upstream of or within early endosome to late endosome transport IDA
IDA: Inferred from direct assay
9412467 MGI
acts upstream of or within epithelial to mesenchymal transition IGI
IGI: Inferred from genetic interaction
21709252 MGI
involved in heart morphogenesis IMP
IMP: Inferred from mutant phenotype
17172441 MGI
involved in negative regulation of neuron projection development IGI
IGI: Inferred from genetic interaction
25358863 MGI
involved in positive regulation of axon regeneration IMP
IMP: Inferred from mutant phenotype
26157139 MGI
involved in positive regulation of potassium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
24951510 MGI
involved in protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
24951510 MGI
involved in regulation of actin filament bundle assembly IMP
IMP: Inferred from mutant phenotype
20713593 MGI
involved in regulation of membrane repolarization during cardiac muscle cell action potential IMP
IMP: Inferred from mutant phenotype
24951510 MGI
involved in semaphorin-plexin signaling pathway IEP
IEP: Inferred from expression pattern
25358863 MGI
involved in semaphorin-plexin signaling pathway IGI
IGI: Inferred from genetic interaction
25358863 MGI
involved in synapse organization IDA
IDA: Inferred from direct assay
26972007 MGI
involved in synapse organization IMP
IMP: Inferred from mutant phenotype
26972007 MGI
Cellular Component GO Annotation Evidence Reference Source
located in Z disc IDA
IDA: Inferred from direct assay
24951510 MGI
located in actin cytoskeleton IDA
IDA: Inferred from direct assay
25358863 MGI
located in actin filament bundle IDA
IDA: Inferred from direct assay
24436304 MGI
located in axonal growth cone IDA
IDA: Inferred from direct assay
26157139 MGI
located in brush border IDA
IDA: Inferred from direct assay
22114352 MGI
located in growth cone IDA
IDA: Inferred from direct assay
25358863 MGI
located in podosome IDA
IDA: Inferred from direct assay
23525008 MGI
located in trans-Golgi network IDA
IDA: Inferred from direct assay
9412467 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

filamin-A

actin-binding protein 280

dilated pupils 2

endothelial actin-binding protein

non-muscle filamin

Related Agents

Clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-139142B Simufilam hydrochloride 99.85% Phase 3
HY-139142 Simufilam 98.08% Phase 3
HY-139142A Simufilam dihydrochloride / Phase 3
Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04979 FLNA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18476 Flna Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24957 Flna Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Flna NCBI NCBI:2316